17例胃小细胞癌临床病理分析  

Clinical analysis of 17 cases of gastric small cell carcinoma

作　　者：刘昊[1] 解亦斌[1] 徐泉[1] 张建伟[1] 田艳涛[1] 赵东兵[1] 王成锋[1] 单毅[1] 周志祥[1] 袁兴华[1] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院腹部外科,100021

出　　处：《中华肿瘤杂志》2013年第4期292-294,共3页Chinese Journal of Oncology

摘　　要：目的分析胃小细胞癌的临床特点，结合文献总结其诊断和治疗方法。方法回顾性分析1999年1月至2012年3月收治的17例经病理证实的胃小细胞癌患者的临床病理资料，并分析国内外报道的胃小细胞癌的临床资料。结果肿瘤位于贲门13例，胃底3例，胃体1例；溃疡型13例，隆起型4例；17例均行手术治疗，其中lO例接受术后化疗，1例接受术前新辅助化疗。本组13例获得随访，2例术后40个月仍生存，3例于术后6个月内死亡。全组患者的中位生存时间为13个月。无淋巴结转移和有淋巴结转移的患者的中位生存时间分别为42和13个月。Ⅱ、Ⅲ期患者的中位生存时间分别为24和14个月。结论胃小细胞癌发病率低，术前、术中常不易确诊，诊断主要依赖术后病理，手术方式需根据肿瘤部位决定，术后采用针对肺小细胞癌的化疗方案可能有助于延长患者的生存时间。Objective To analyze the clinical data and prognosis of gastric small cell carcinoma （ GSCC ） , summarize recent progress in diagnosis and therapy of this disease reported in the literature, and to provide the theoretical basis for its appropriate treatment. Methods Clinicopathological data of 17 patients with pathologically confirmed GSCC, treated in our hospital between 1999 to 2012, were retrospectively reviewed. Results There were 16 males and 1 female, ranged from 46 to 75 years （ mean 64.6 years）. The tumor was located in the gastric cardia in 13 cases, three in the gastric fundus, and one in the gastric body. All the 17 patients received surgery and l0 of them received postoperative adjuvant chemotherapy, one received preoperative adjuvant chemotherapy. Thirteen patients were followed up. Among them, two lived for 40 months all along, the other 3 cases died of recurrence and extensive metastasis in 6 month after operation. The median survival was 13.0 months. The median survival of the patients with and without lymph node metastasis were 42 months and 13 months, respectively. The median survival time of stage ]] and HI patients were 24 months and 14 months, respectively. Conclusions It is difficult to make a definite diagnosis before or during the operation for GSCC. Radical operation could be done according to other gastric cancers and lymph node dissection could be simplified. Postoperative chemotherapy with the same scheme as lung small cell carcinoma may help to improve the outcome and prolong the survival of the patients.

关 键 词：胃肠肿瘤 胃肠小细胞癌 化学疗法 辅助 

分 类 号：R735[医药卫生—肿瘤]