Smac和survivin在鼻腔鼻窦内翻性乳头状瘤中的表达  

The expression of Smac and survivin in nonasal inverted papilloma

作　　者：杨莉晖[1] 单春光[2] 黄红梅[1] 孙怡君[1] 赵颖[1] 王利军[1] 贾文学[1] 

机构地区：[1]石家庄市中心医院耳鼻咽喉科,石家庄050011 [2]河北医科大学第二医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第8期407-410,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：2011年石家庄市科学技术研究及发展指导计划(No:11146403)

摘　　要：目的:研究第2个线粒体衍生的半胱氨酸蛋白酶激动剂(Smac)和凋亡抑制基因survivin在鼻腔鼻窦内翻性乳头状瘤(NIP)的发生、发展和恶变过程中的表达情况。方法:选取因鼻中隔偏曲对侧下鼻甲代偿肥大而行下鼻甲部分切除术的下鼻甲黏膜标本(对照组)10例、经病理证实为NIP的患者(NIP组)45例,其中的NIP组根据不同的病理分级分为3组:无不典型增生组25例,不典型增生组11例和恶变组9例,通过免疫组织化学SP法进行Smac及survivin的检测。结果:Smac在NIP组中的阳性表达强度弱于在对照组中的表达,阳性表达强度随NIP病理分化程度的降低而降低,在无不典型增生组及恶变组间的表达差异具有统计学意义。survivin在对照组中为阴性表达,在NIP组中的表达强度增强,NIP组织的分化程度越低,阳性表达强度越高,在无不典型增生组及恶变组间的表达差异有统计学意义。Smac与survivin的表达呈负相关(rs=-0.403,P<0.01)。结论:Smac和survivin与NIP的发病及恶变相关。Objective：To explore the expression of Smac（secondmitochondria-derived activator of caspase）and survivin on the growth, development, recurrence and carcinogenesis of the nonasal inverted papilloma（NIP）. Meth- od：Immunohistoehemical method was used to detective the expression of Smac and survivin in 10 cases of （nasal cavity mucosae,NM）,45 cases of NIP. The NIP group including 25 eases of NIP without dysplasla, 11 cases of NIP with dysplasia, and 9 cases of NIP with malignant transformation to squamous cell carcinoma（SCC）. Result： The intensity of the positive expression of Smac in NIP was lower than NM, the intensity of the positive expres- sion decreased with the decreasing degree of histological differentiation. There was significantly difference between NIP without dysplasia and SCC. The expression of survivin was negative in the control group, the expression in- tensity of NIP was enhanced. The degree of histological differentiation was lower, the intensity of the positive ex- pression was higher. The expression between NIP without dysplasia and SCC had significantly differences. Smae negatively correlated with survivin（r = -0. 403, P（0.01）. Conclusion ： Smae and survivin were associated with the growth and carcinogenesis of NIP.

关 键 词：鼻窦肿瘤 乳头状瘤 内翻 SMAC SURVIVIN 免疫组织化学 

分 类 号：R739.62[医药卫生—肿瘤]