Livin和HIF-1α在膀胱尿路上皮癌中的表达及意义  

Expression and significance of Livin and HIF-1α protein in carcinoma of urinary bladder

作　　者：张勇[1] 陈忠[1] 杨为民[1] 叶章群[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,武汉430030

出　　处：《临床泌尿外科杂志》2013年第4期268-270,共3页Journal of Clinical Urology

摘　　要：目的:探讨凋亡抑制蛋白Livin和缺氧诱导因子-1α(HIF-1α)在膀胱尿路上皮癌组织中的表达及其与膀胱尿路上皮癌复发的关系。方法:应用免疫组化SABC法检测45例膀胱尿路上皮癌及15例正常膀胱黏膜组织石蜡切片中Livin和HIF-1α的表达情况,并结合临床资料进行分析。结果:45例膀胱尿路上皮癌组织中分别有23(51.1%)例Livin阳性和39(86.7%)例HIF-1α阳性。在正常组织中有1(6.7%)例Livin阳性,3(20.0%)例HIF-1α阳性。二者在膀胱尿路上皮癌组织中的表达均明显高于相应正常膀胱组织(P<0.01)。Livin蛋白和肿瘤复发成正相关,病理分级之间存在差异;但Livin和HIF-1α的表达均与膀胱尿路上皮癌的临床分期和患者年龄无关(P>0.05);此外,HIF-1α在病理分级上也无显著差异;Livin与HIF-1α之间也不存在相关性。结论:检测Livin和HIF-1α蛋白有助于评估肿瘤的生物学行为,并有利于膀胱尿路上皮癌患者的临床治疗决策。Objective：To investigate the expression of the inhibitor of apoptosis protein Livin and HIF-lalpha/ HIF-lα in human carcinoma of urinary bladder and their relationship with cancer development and relapse. Method.. The expression of Livin and HIF-lα protein in 45 carcinoma of urinary bladder specimens and 15 corresponding normal mucosa tissues were detected by immunohistochemieal staining. Result： Livin and HIF-lαprotein positive expression rate in tumor samples were 51. 1% （23/45）, 86. 7% （39/45）, respectively. While Livin and HIF- l aprotein positive expression rate in corresponding normal mucosa tissues samples were 6.7 % （1/45）, 20.0 % （3/ 15）, respectively. The expression of Livin and HIF-lα protein in the carcinoma of urinary bladder were significantly higher than normal tissue （ P d0.01）. Tumor recurrence and tumor stage were found with expression of Livin. But no correlation was found between the expression of Livin and HIF-lα in tumor grade and age（P〉0. 05）. There was no significant correlation between the expression of Livin and HIF-lα. Conclusion：The determina- tion of Livin and HIF-lα will be useful in predicting tumor biological behavior and may help for clinical decisionmaking in the treatment of carcinoma of urinary bladder patients.

关 键 词：膀胱尿路上皮癌 LIVIN HIF-1Α 免疫组化 

分 类 号：R737.14[医药卫生—肿瘤]