青光眼患者视网膜神经节细胞凋亡机制的研究进展  

Research advances on mechanism of apoptosis in retinal ganglion cells in glaucoma

作　　者：陈莲[1] 石晶明[1] 

机构地区：[1]中南大学附属湘雅二医院眼科,湖南省长沙市410011

出　　处：《眼科新进展》2013年第4期384-388,共5页Recent Advances in Ophthalmology

基　　金：湖南省自然科学基金资助(编号:10JJ6031);湖南省科技厅基金资助(编号:2009-130)~~

摘　　要：青光眼的病理基础是视网膜神经节细胞(retinal ganglion cell,RGC)以凋亡的形式选择性丢失。通过制作青光眼动物模型,越来越多的机制被发现参与启动凋亡信号通路,并最终导致程序性细胞死亡和RGC的丢失。我们将总结青光眼RGC凋亡的过程以及牵涉其凋亡的各种分子机制,为靶向RGC的青光眼神经保护治疗方法提供理论依据。Pathological basis of glaucoma is the selective loss of retinal ganglion cells（RGC）by apoptosis.More and more mechanisms have been proved to be involved in activating apoptotic signaling pathway,and resulting in programmed cell death and loss of RGC.In this review,we summarize the process of RGC apoptosis and various molecular mechanisms that are implicated in it.This review may provide theoretical basis for neuroprotective strategies in treating RGC-targeted glaucoma.

关 键 词：凋亡 视网膜神经节细胞 青光眼 

分 类 号：R775[医药卫生—眼科]