^18F-FDG PET/CT显像在评估胆囊癌预后中的价值  

Role of^(18)F-FDG PET/CT imaging in the prognosis of gallbladder carcinoma

作　　者：汪娇[1] 戴东[1] 宋秀宇[1] 朱研佳[1] 张莹[1] 徐文贵[1] 

机构地区：[1]天津医科大学附属肿瘤医院分子影像与核医学诊断科天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2013年第7期410-413,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨治疗前18F-FDG PET/CT显像在胆囊癌患者预后中的作用。方法:回顾2005年4月至2012年11月临床可疑胆囊癌并行18F-FDG PET/CT检查的95例患者,分析PET/CT显像及其他相关因素与患者预后之间的关系,研究PET/CT显像在评估胆囊癌预后中的价值。结果:Kaplan-Meier单因素分析显示A组(SUVmax值≤8.5)与B组(SUVmax值>8.5)患者的中位生存时间(266,166天)差异有统计学意义(P<0.05);PET/CT分期不同的患者之间的生存时间有显著性差异(P<0.05)。Cox多因素分析显示SUVmax值、术前血清CA19-9水平和治疗情况是本组患者生存预后的独立影响因素。结论:PET/CT分期及肿瘤原发部位的SUVmax值在评估胆囊癌患者预后方面具有一定的临床价值,能够指导临床尽早制定个体化治疗方案,提高胆囊癌的早期诊断率,可望延长患者生存期。Objective： This study aimed to evaluate the role of 18F-FDG PET/CT imaging in predicting the prognosis of patients with gallbladder carcinoma. Methods： A total of 95 patients who were clinically suspected with gallbladder carcinoma from April 2005 to November 2012 were examined by 18F-FDG PET/CT. All cases were confirmed for gallbladder carcinoma; 68 cases were found to be pathological, and 27 were found to be long-term clinical follow-up cases. The relationship of PET/CT imaging date and other factors with the survival of the 95 patients with gallbladder carcinoma were retrospectively analyzed to evaluate the role of PET/CT imaging in the prognosis of patients with gallbladder carcinoma. Results： A total of 51 patients died and 44 patients survived out of the 95 patients with gallbladder carcinoma. Kaplan-Meier analysis showed that the survival time of patients in group A （SUVmax≤8.5） and group B （SUVmax〉8.5） was statistically different （266, 166） at P〈0.05. The survival time of patients belonging to different PET/CT staging was also statistically different at P〈0.05. Cox multi-factor analysis indicated （maximum standardized uptake values, SUVmax） that the preop-erative serum （CA19-9） level and treatment methods were all independent risk factors that prevented the long-term survival of the pa-tients. Conclusion： PET/CT staging and SUVmax of the primary tumor before treatment are important in estimating the prognosis of patients with gallbladder carcinoma. PET/CT staging and SUVmax can be utilized to set immediate individualized treatment, improve the curative effect, and extend the lifespan of patients with gallbladder carcinoma.

关 键 词：胆囊癌 正电子发射型计算机断层扫描 18F-FDG SUV值 预后 

分 类 号：R735.8[医药卫生—肿瘤]