Sirius与A超测量中央角膜厚度对比研究  

Comparative study of central corneal thickness measurements with Sirius and ultrasound pachymetry

作　　者：张玙[1] 晏丕松[1] 杜之渝[1] 孔俐[1] 范罕英[1] 

机构地区：[1]重庆明达眼科 重庆医科大学附属第二医院眼科中心,400050

出　　处：《中国实用眼科杂志》2013年第4期412-416,共5页Chinese Journal of Practical Ophthalmology

摘　　要：目的探讨Sirius三维角膜地形图及眼前节分析仪测量前弹力层下准分子激光原位角膜磨镶术（SBK）术前及术后患者中央角膜厚度（CCT）的重复性，以及其与A超角膜测厚仪测量结果的一致性和差异性。方法临床病例回顾性研究。收集2011年5月至11月于重庆明达眼科门诊接受SBK手术的近视患者35例（68只眼），回顾性分析术前及术后2周、1月、3月Sirius和A超测量的CCT值，采用组内相关系数（ICC）评价Sirius测量值的重复性，配对资料f检验评价两种方法所测得角膜厚度的差异性，Bland—Altman法检验其一致性，Pearson直线相关分析检验其相关性，重复测量的方差分析比较术前与术后CCT的变化情况。结果Sirius的测量结果稳定，重复性好，SBK术前、术后2周、1月、3月测量CCT的组内相关系数（mC）分别为0．988、0．993、0．992、0．996。Sirius与A超具有较好的一致性，95％的一致性界限术前、术后2周、1月、3月分别为-14．04～±11．20μm、-21．10～±5．16μm、-28．00～±10．76μm、-27．18～±12．30nm。Sirius与A超的测量值具有显著的正相关性，术前、术后2周、1月、3月CCT的相关系数r分别为0．970、0．987、0．980、0．978。术前CCT的测量值Sirius为（541．45±25．78）μm，A超为（542．87±23．41）μm，两者测量结果差异无统计学意义（P〉0．05）；术后2周、1月、3月Sirius的CCT测量值分别为（428．29±43．30）μm、（430．02±45．71）μm、（435．73±46．10）μm，A超的CCTN量值分别为（436．26±41．61）μm、（438．65±41．14）μm、（443．16±42．91）μm，Sirius测得的值均小于A超，两者差异均有统计学意义（P〈0．01）。结论Sirius测量SBK术前及术后中央角膜厚度具有很好的重复性，与A超角膜测厚仪之间具有较好的一致性和显著的正相关性，但术后两者测量值存在一定的差异性。Objective To assess the repeatability of central corneal thickness （CCT） performed by Sirius before and after SBK, and to compare the agreement and differentiation of the Sirius with ultrasound pachymetry in the measurements of CCT. Methods Retrospective case series. Sixty eight myopic eyes of 35 consecutive patients in Chongqing Medal Eye Institute from May to Novenber 2011 were enrolled in this study. Central corneal thicknesses were examined using Sirius and ultra- sound pachymetry preoperatively and at two weeks, one month, three months postoperatively. The da- ta were analyzed using intraclass correlation coefficient （ICC）, paired t tests, the correlation coeffi- cient, the Bland-Altman technique and repeated measures analysis of variance. Results The ICC of the Sirius were 0.988 （pre-op）, 0.993 （2 w）, 0.992 （1 mo）, 0.996 （3 mo）, respectively. The 95% lim- its of agreement in CCT were -14.04 to ll.20μm （pre-op）, -21.10 to 5.16μm （2 w）, -28.00 to 10.761a m （1 mo）, -27.18 to 12.30μm （3 too） , respectively. The CCT values of the Sirius and ultrasound pachymetry were positively related by linear correlation analysis, r =0.970 （pre-op）, 0.987 （2 w）, 0.980 （1 mo）, 0.978 （3 too）. The preoperative CCT measurements by Sirius and ultrasound pachyme- try were （mean standard deviation） （541.45±25.78）μm, （542.87±23.41）μ, respectively. Preoperative Sirius was not significantly different compared to ultrasound pachymetry （P 〉0.05）. Postoperative Siri- us measurements were （428.29±43.30）μm （2 w）, （430.02±45.71）μm （1 mo）, （435.73±46.10）μm （3 mo）, respectively. Ultrasound pachymetry measurements were （436.26±41.61）μm （2 w）, （438.65±41.14）μm （1 too）, （443.16±42.91）μm （3 mo）, respectively. Postoperative measurements were significant dif- ference between Sirius and ultrasound pachymetry （P 〈0.01）. Conclusions The measurements of CCT with Sirius yield excellent repeatability. There is

关 键 词：Sirius A超 中央角膜厚度 SBK 

分 类 号：R778.11[医药卫生—眼科]