^(18)F-FDG PET-CT在非小细胞肺癌术前分期中的应用价值  

Value of ^(18)F-FDG PET-CT in the preoperative staging of non-small cell lung cancer

作　　者：王广丽[1] 张成琪[1] 范医鲁[2] 邓凯[1] 宋吉清[3] 陈静[3] 

机构地区：[1]山东省千佛山医院放射科,济南250014 [2]山东省千佛山医院医学工程部,济南250014 [3]山东省立医院放射科,济南250021

出　　处：《放射学实践》2013年第4期397-400,共4页Radiologic Practice

基　　金：山东省科技攻关项目(2009GG10002040)

摘　　要：目的:评价18F-FDG PET-CT在非小细胞肺癌患者术前分期中的临床应用价值。方法:回顾性分析经病理证实的112例非小细胞肺癌患者的18F-FDG PET-CT资料,并与病理结果及随访结果进行对照分析。结果:非小细胞肺癌原发灶主要表现为病灶部分或全部呈放射性浓聚。术前对非小细胞肺癌PET-CT T分期与术后T分期相比符合率为T1、T2、T3、T4期分别为87.50%、95.56%、90.48%、100%,T分期的总体符合率为93.75%,与最终诊断结果高度一致(kap-pa=0.929,P=0.000)。N分期的符合率N0和N3期均为100%,N1期63.16%,N2期90.91%,N分期总体符合率为91.96%,与最终诊断结果高度一致(kappa=0.928,P=0.000)。M分期诊断符合率为96.97%(kappa=0.957,P=0.000)。结论:18F-FDG PET-CT对非小细胞肺癌患者的术前TNM分期与术后分期具有高度的一致性,具有重要的临床应用价值。Objective： To study the value of ^18 F-FDG PET-CT for the evaluation of pre-operative clinical staging of non-small cell lung cancer （NSCLC）. Methods：^18 F-FDG PET-CT materials of 112 patients with pathology proved NSCLC were retrospectively analyzed and correlated with the results of pathology and follow-up. Results： The main PET-CT mani- festations of NSCLC were intense uptake of ^18 F-FDG in part or total region of tumor. Compared with the post-surgical stag- ing,the corresponding rate of pre-surgical T staging with PET-CT for T1 ,T2,T3 and T4 was 87.50%, 95.56%, 90.48% and 100% respectively. The overall accuracy rate of T staging was 93.75%, which was highly corresponded with the final diagnosis（kappa=0. 929,P=0. 000）. The accuracy of N staging for NO, N3 was 100% respectively,for N1 and N2 was 63.16 % and 90.91% respectively. The overall accuracy of N staging was 91.96 %, which was highly corresponded with the final diagnosis （kappa= 0. 928, P = 0. 000）. The corresponding rate of M staging was 96.97 % （kappa= 0. 957, P= 0. 000）. Conclusion： The preoperative TNM staging of non-small cell lung cancer with ^18 F-FDG PET-CT was highly corresponded with the final diagnosis and have a significant value in clinical application.

关 键 词：肺肿瘤 体层摄影术 X线计算机 诊断 正电子发射断层摄影术 

分 类 号：R734.2[医药卫生—肿瘤]