结直肠癌发生机制研究进展  

Advances in Study on Pathogenesis of Colorectal Cancer

作　　者：陈慧[1] 詹俊[1] 

机构地区：[1]中山大学孙逸仙纪念医院消化内科,510120

出　　处：《胃肠病学》2013年第3期188-190,共3页Chinese Journal of Gastroenterology

摘　　要：结直肠癌是最常见的恶性肿瘤之一,其发生由遗传和环境等诸多因素相互作用所致,是一个涉及多基因、多阶段的复杂过程。本文就结直肠癌发生机制包括染色体不稳定(CIN)、微卫星不稳定(MSI)、CpG岛甲基化表型(CIMP)等的研究进展作一综述。Colorectal cancer is one of the most common malignant tumors. The genesis of colorectal cancer is the result of interaction between genetic and environmental factors, and is a muhi-gene, multi-step process. This article reviewed the advances in study on pathogenesis of colorectal cancer, including chromosome instability （CIN）, microsatellite instability （MSI） and CpG island methylator phenotype （CIMP）.

关 键 词：结直肠肿瘤 分子作用机制 治疗 

分 类 号：R735.3[医药卫生—肿瘤]