口服复方聚乙二醇-4000前吞服比沙可啶对简化CT结肠镜肠道清洁准备的作用  

Effect of gulping down Bisacodyl prior to oral taking compound polyethylene glycol-4000 for preparation of CT colonography

作　　者：陈志远[1] 沈合松[1] 罗明月[1] 段侪杰[2] 卢虹冰[3] 张国鹏[3] 刘洋[3] Wen-Li CAI Jerome Z LIANG 

机构地区：[1]中山大学附属第六医院放射科,广东广州510655 [2]清华大学深圳研究生院生物医学工程研究中心,广东深圳518055 [3]第四军医大学生物医学工程系,陕西西安710032 [4]麻省总医院与哈佛医学院放射科,美国波士顿02114 [5]纽约州立大学石溪分校放射与计算机科学系,美国石溪11794

出　　处：《中国医学影像技术》2013年第4期577-581,共5页Chinese Journal of Medical Imaging Technology

基　　金：广东省科技计划项目(2011B031800182)

摘　　要：目的探讨口服复方聚乙二醇-4000前吞服比沙可啶对简化CT结肠镜肠道清洁准备的作用。方法将40例接收CT结肠镜检查的患者随机均分成试验组、对照组。检查前1天,试验组三餐前口服40%W/V硫酸钡20ml,晚餐后将60%泛影葡胺20ml溶于250ml水并服完,口服2L复方聚乙二醇-4000电解质液之前1h吞服10mg比沙可啶肠溶片;对照组不吞服比沙可啶,其余同试验组。统计分析两组结直肠存留肠液评分、存留肠液CT值及存留粪块评分。结果试验组存留肠液平均评分(1.50±0.06)低于对照组(1.78±0.08),差异有统计学意义(P=0.024)。试验组、对照组存留肠液平均CT值分别为(729±29)HU、(597±27)HU,差异无统计学意义(P>0.05)。试验组存留粪块评分(1.96±0.11)低于对照组(2.63±0.12),差异有统计学意义(P=0.001)。结论口服复方聚乙二醇-4000前吞服比沙可啶既可增强对肠液的清洁能力,又不影响存留肠液CT值,同时可增强对肠道粪块的清洁能力,较单独口服复方聚乙二醇-4000的肠道清洁效果好,是CT结肠镜前较好的简化肠道准备方法。Objective To explore the effect of gulping down 10 mg bisaeodyl prior to oral taking compound polyethylene glycol 4000 for preparation of CT colonography. Methods Forty patients who underwent CT colonography were assigned to experiment or control group randomly. On the day before CT colonography, patients in experiment group orally took 20 ml of 40~ W/V barium sulfate before 3 mealtime and 20 ml of 60 diatrizoate meglumine diluted in 250 ml of water af- ter dinner, then gulped down 10 mg bisacodyl enteric-coated tablets 1 h before oral administration of 2 liter compound poly- ethylene glycol-4000 electrolyte solution. Patients in control group were identical to experiment group except of not taking bisacodyl. The remnant fluid scores, attenuation value of remnant fluid and residual stool scores between two groups were analyzed statistically. Results The average score of remnant fluid of experiment group （1.50!0.06） was lower than that of control group （1.78＋0.08, P--0. 024）. The mean attenuation value of residual fluid of experiment group and control group was （729＋29）HU and （597127）HU, respectively （P^0.05）. The mean score of remnant stool of experiment group （1.96＋0. 11） was lower than that of control group （2.63＋0.12, P=0. 001）. Conclusion Gulping down bisacodyl before oral taking compound polyethylene glycol-4000 can increase the ability to cleansing fluid without impact on the atten- uation value of residual fluid, and improve the capability of clearing away remnant stool with better bowel cleansing than o- ral administration of compound polyethylene glycol 4000 alone, therefore is a fine way for colorectal preparation of CT colonography.

关 键 词：结肠肿瘤 筛查 聚乙烯二醇类 比沙可啶 

分 类 号：R735.35[医药卫生—肿瘤] R814.42[医药卫生—临床医学]