慢性心力衰竭患者血清CA125水平及其与BNP的相关性研究  

Correlation of serum CA 125 levels with BNP in patients with chronic heart failure

作　　者：钟鸣[1] 傅慎文[1] 朱以军[1] 郑新玲[1] 徐育红[1] 

机构地区：[1]金华市中心医院心内科,321000

出　　处：《浙江医学》2013年第5期368-369,408,共3页Zhejiang Medical Journal

基　　金：浙江省医学会临床科研基金项目（2011ZYC-A98）

摘　　要：目的评估慢性心力衰竭患者血清CA125水平，研究血清CA125与B型脑钠肽（BNP）之间的相关性。方法选择住院患者64例，男29例，女35例，年龄55～83（68±15）岁。据纽约心功能（NYHA）分级分为NYHAⅠ～Ⅱ、NYHAIII与NYHAIV级3组，血清CA125及BNP均在入院24h测定。结果血清CA125水平NYHAI／II级组为（21．6±6．2）U／mI，NYHAIII级组为（350±617）U／mI，NYHAIV级组为（59.0±24．0）U／m1。NYHAIV级和NYHAIII级组CA125均高于NYHAⅠ～Ⅱ级组（t=7．3、6．8，均P〈0．01）。相关分析显示血清CA125与BNP呈正相关（r=0．77，P〈0．01）。结论血清CA125反映慢性心力衰竭的严重程度，CA125与BNP相关，两者结合可作为心力衰竭的重要诊断依据。Objective To assess the correlation of serum carbohydrate antigen 125 （CA125） levels with B-type natriuretic peptide （BNP） in patients with chronic heart failure. Methods Sixty four hospitalized patients with chronic heart failure were enrolled, including 29 males and 35 females aged 55-83y （mean 68 ± 15y）. The heart functions were classified as NYHA class 1/11, III and IV according to New York Heart Association （NYHA）. Serum CA125 and plasma BNP was measured within 24h after admission. Results The mean CA125 level was 39.4 ± 21.5 U/ml, that for NYHA 1/11, III and IV was 21.6 ± 6.2 U/ml, 35.0 ± 6.7 U/ml and 59.0 ± 24.0 U/ml, respectively. Serum CA125 levels in patients of NYHA IV and II1 were significantly higher than that in patients of 1/11 （t=7.3, 6.8, P〈0.01 andP〈0.05 ）. Serum CA125 levels were significantly correlated with BNP levels（r=0.77, P〈 0.01 ）. Conclusion Serum CA125 and BNP levels are correlated with clinical severity of chronic heart failure, which may have diagnostic value.

关 键 词：慢性心力衰竭 糖蛋白抗原125 B型脑钠肽 

分 类 号：R737.31[医药卫生—肿瘤]