饮食诱导肥胖与肥胖抵抗大鼠ATP生成量的比较  

The comparison of ATP contents between diet-induced obesity group and diet-induced obesity resistance group

作　　者：王双[1] 胡丽贞[1] 于海涛[1] 梁冰[1] 薛宏凤[1] 李雅杰[1] 王舒然[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院营养与食品卫生学教研室,黑龙江哈尔滨150081

出　　处：《中华疾病控制杂志》2013年第4期291-294,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81072297)

摘　　要：目的比较饮食诱导肥胖大鼠与肥胖抵抗大鼠三磷酸腺苷(adenosine triphosphate,ATP)生成量的差异。方法将健康雄性远交群(sprague dawley,SD)大鼠,随机分为基础饲料(control,CON)组和高脂饲料组,喂养2周后,将高脂饲料组按照体重增加量分为饮食诱导肥胖(diet-induced obesity,DIO)组和饮食诱导抵抗(diet-in-duced obesity resistance,DR)组。于喂养第10周末,麻醉处死动物,观察体重、摄食量、能量利用率以及肝脏、心脏、肌肉组织中ATP生成量的情况。结果 DIO组的体重一直高于DR组(均有P<0.05)。DIO组总能量摄入高于DR组和CON组(均有P<0.001),但DIO组与DR组能量利用率差异无统计学意义。DR组大鼠肝脏、心脏和肌肉组织中ATP生成量比DIO组分别高出12.8%,30.6%和11.6%。结论饮食诱导肥胖和肥胖抵抗大鼠的能量代谢存在差异,这种差异可能与主要能量器官中ATP的生成量有关。Objective To compare the ATP contents in tissues between diet-induced obesity（DIO） group and di- et-induced obesity resistance （DR） group. Methods Forty-eight male sprague dawley （SD） rats were randomly divided into control group and high-fat group which were given different diets. After 2-week feeding, the high-fat group were divid- ed into diet-induced obesity group and diet-induced obesity resistance group. The rats were sacrificed for tissues and blood sample at the end of week 10. Results The body weight of D10 group was higher than that of DR group during the feeding （ all P 〈 0. 05 ）. The total energy intake of DIO group was higher than that of DR group and CON group （ all P 〈 0. 001 ）. No significance were observed of energy utilization between DIO group and DR group. The ATP contents of DIO group were 12.8%, 30. 6%, and 11.6% lower than that of DR group in liver, cardiac and muscle separately. Conclusions The differences of energy utilization between DO group and DR group may be related with the ATP contents in liver, cardiac and muscle.

关 键 词：肥胖症 能量代谢 ATP 

分 类 号：R151.4[医药卫生—营养与食品卫生学]