安庆地区农村人群腰高比与脑卒中发病关系的研究  

The study of waist-to-height ratio and risk of stroke in Anqing rural areas

作　　者：胡晶晶[1] 王缓[1] 吴飞[1] 唐根富[1] 邢厚恂 谢迪[3] 蔡业锋[4] 王滨燕[1] 臧桐华[1] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032 [2]连云港市现代心血管病防治研究中心,江苏连云港222006 [3]南方医科大学肾病研究所,广东广州510515 [4]广东省中医院神经内科,广东广州510120

出　　处：《中华疾病控制杂志》2013年第4期302-305,共4页Chinese Journal of Disease Control & Prevention

基　　金：中国科技部973项目(2012CB517703)

摘　　要：目的探讨农村人群中腹部肥胖指标——腰高比(waist-to-height ratio,WHtR)与脑卒中的发病关系。方法对安庆及其周边地区在1995-2005年间参加前期流行病学研究的队列人群进行健康回访。采用COX比例风险模型来探讨腰高比与脑卒中的发病关系。结果纳入分析18 963人,中位随访时间为6.3年,共发生371例脑卒中,经年龄、性别(分析总人群时)、吸烟、饮酒多变量调整后,总人群中腰高比每增加0.1,发生脑卒中、脑梗死和脑出血的风险比(hazard ratio,HR)分别为1.75(95%CI:1.47～2.09)、2.18(95%CI:1.59～2.99)和1.67(95%CI:1.20～2.30),男性中对应的HR分别为1.69(95%CI:1.32～2.16)、2.35(95%CI:1.50～3.68)和1.60(95%CI:1.03～2.48),女性中对应的HR分别为1.86(95%CI:1.45～2.38)、2.09(95%CI:1.34～3.26)和1.82(95%CI:1.12～2.97);进一步调整收缩压和舒张压之后,在总人群中,腰高比每增加0.1仍能增加50%的脑梗死发病风险,对应的HR值为1.50(95%CI:1.08～2.09);而分别在男女性别中,腰高比与脑卒中发病风险的关联无统计学意义。结论农村人群中,腰高比的升高增加脑卒中及其亚型的发病风险,但是这种关系在一定程度上受到血压的影响,在总人群中腰高比是脑梗死的独立危险因素。Objective To investigate the relationship between waist-to-height ratio（WHtR） and stroke in Anqing rural areas. Methods The participants who were enrolled from 1995 to 2005 at baseline studies in Anqing and the sur- rounding communities were investigated. Cox＇ s proportional hazard model was used to investigate the association between waist-to-height ratio and stroke. Results 18 963 participants were selected into the analysis. During a median of 6. 3 years follow-up, 371 participants developed stroke events. In the total study population, the multivariate-adjusted hazard ratios（95% CI） for each 0. 1 increased in WHtR were 1.75（95% CI：1. 47-2. 09） for total stroke, 2. 18（95% CI： 1.59- 2. 99） for ischemic stroke and 1.67 （95% CI： 1.20-2. 30） for cerebral hemorrhage stroke. Among men, the corresponding HRs were 1.69 （95 % CI： 1.32-2. 16） for total stroke, 2. 35 （95 % CI：1. 50-3.68 ） for ischemic stroke and 1.60 （95 % CI： 1.03-2.48 ） for cerebral hemorrhage stroke. Among women, the corresponding HRs were 1.86 （95 % CI ： 1.45-2. 38 ） for to- tal stroke, 2. 09（95% CI：I. 34-3.26） for ischemic stroke and 1.82（95% CI： 1.12-2. 97） for cerebral hemorrhage stroke. Additional adjusted for systolic pressure and diastolic pressure, WHtR could significantly increase the ischemic stroke risk in total study population, the HR was 1.50 （95% CI： 1.08-2. 09 ） ; in men and women, no significant association between WHtR and stroke was observed. Conclusions In rural areas population, WHtR can increase the risk of stroke and sub- types, but the relationships were highly modified by systolic pressure and diastolic pressure in certain degree. WHtR is an independent risk factor for ischemic stroke in total population.

关 键 词：农村人群 脑卒中 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]