七种恶性肿瘤患者血清CK和CK-MB含量分析  

Analyses of Serum CK and CK-MB Levels in Patients with Seven Kinds of Malignant Tumors

作　　者：丁慧[1] 董振南[1] 温新宇[1] 田亚平[1] 

机构地区：[1]解放军总医院生化科,北京100853

出　　处：《标记免疫分析与临床》2013年第2期87-89,共3页Labeled Immunoassays and Clinical Medicine

基　　金：国家科技支撑计划2009BAI86B05

摘　　要：目的比较肌酸激酶(CK)及其同工酶(CK-MB)在正常人群和恶性肿瘤患者的含量及其异常率。方法检测前列腺癌组患者108例,胃癌组患者139例,乳腺癌组患者101例,胰腺癌组患者160例,结肠癌组患者101例,肺腺癌组患者71例,宫颈癌组患者72例,和健康对照组200名人群血清CK和CK-MB含量。结果前列腺癌组CK含量与正常对照组相比较,有显著升高,差异有统计学意义(P<0.05);而六种恶性肿瘤组与正常对照组之间差异无统计学意义(P>0.05)。七组恶性肿瘤患者CK-MB含量与正常对照组相比较,差异均无统计学意义(P>0.05)。七组恶性肿瘤患者CK-MB异常率与正常对照组相比,均显著升高,差异有统计学意义(P<0.05),胃癌组的异常率最高,乳腺癌组次之。结论前列腺患者CK含量会异常升高,胃癌与乳腺癌患者CK-MB异常率较高。Objective To compare the serum levels and abnormal rate of CK and its CK- MB in the normal control and patients with seven kinds of cancer. Methods The serum levels of CK and CK-MB were detected in 108 prostate cancer patients, 139 gastric cancer patients, 101 breast cancer patients, 160 pancreatic cancer pa- tients, 101 colon cancer patients, 71 lung adenocarcinoma patients, 72 cervical cancer patients, and 200 healthy controls. Results Compared with the healthy control, the serum levels of CK in prostate cancer patients showed significantly increased （P 〈 0.05 ） , while there was no significant difference in patients with other six kinds of cancer. Compared with the healthy control, the serum levels of CK-MB in patients with seven kinds of cancer showed no significantly difference. The abnormal rates of serum CK-MB in patients with seven kinds of cancer were significantly higher than that the healthy controls; the highest abnormal rate was in gastric cancer. Conclusion The serum levels of CK in patients with prostate cancer were significantly increased. The abnormal rates of CK-MB in gastric cancer and breast cancer group were significantly higher.

关 键 词：肌酸激酶 肌酸激酶同工酶-MB 恶性恶性肿瘤 前列腺癌 胃癌 乳腺癌 全自动生化分析仪 

分 类 号：R730.4[医药卫生—肿瘤]