基于PCA和Fisher判别分析的锋电位在线分类算法  

Online spike sorting with PCA and Fisher discriminant analysis

作　　者：卢小银[1] 梁振[2] 周保琢[1] 周逸峰[3] 

机构地区：[1]中国科学技术大学电子科学技术系,合肥230027 [2]安徽医科大学生命科学学院,合肥230032 [3]中国科学技术大学生命科学学院,合肥230027

出　　处：《北京生物医学工程》2013年第2期122-126,133,共6页Beijing Biomedical Engineering

基　　金：中央高校基本科研业务费专项资金(WK2100230002)资助

摘　　要：目的大脑神经元胞外单细胞动作电位(即锋电位)的检测与分类,是研究神经系统处理信息机制的关键。常用方法是实验完成后对记录到的数据进行离线检测与分类,然而当需要在短时完成大量数据的处理或无线传输时,则需实现锋电位的在线检测与分类。方法为实现在线分类,本文在利用主成分分析法(principal component analysis,PCA)和K均值分类法对一定量数据进行预分类的基础上,提出使用PCA结合Fisher判别分析的方法,并与基于距离的模板匹配法、BP神经网络分类法进行了分类效果和算法复杂度的比较。结果仿真结果表明,该方法相对于其它两种方法在分类效果和算法复杂度上都具有一定的优势。结论此方法是实现锋电位在线分类的不错选择。Objective The detection and separation of neuron action potentials （spikes）is a key of information processing mechanism in the neural system research. Offline spike sorting approaches are currently used to detect and sort action potentials after experiments. Online sorting and detecting algorithms are required when researchers need to analyze or wireless transmit a large number of recordings in a short time. Methods To realize online spike sorting, we propose an algorithm combining Fisher discriminant analysis with principal component analysis（PCA）after performing a preprocessing with PCA and K-means. We test this algorithm and compare the efficiency and complexity with the other two algorithms：template matching based on distance and back propagation neural networks. Results The simulation results indicate that this method has an advantage over the other two methods in both efficiency and complexity. Conclusions This online spike sorting algorithm is effective.

关 键 词：锋电位 在线分类 主成分分析 FISHER判别分析 模板匹配 神经网络 

分 类 号：R318.04[医药卫生—生物医学工程]