度洛西汀对躯体形式障碍患者情绪图片信息认知偏倚的影响  被引量:3

Effect of duloxetine treatment on cognitive bias to the emotional facial information in patients with somatoform disorder

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作  者:陈琳[1] 周振和[1] 程灶火[1] 袁国桢[1] 

机构地区:[1]南京医科大学附属无锡精神卫生中心临床精神科

出  处:《临床精神医学杂志》2013年第2期92-95,共4页Journal of Clinical Psychiatry

基  金:江苏省卫生厅医学科研面上课题(H201043)

摘  要:目的:探讨度洛西汀对躯体形式障碍患者情绪图片信息认知偏倚的影响。方法:选择30例躯体形式障碍患者作为研究组,与研究组匹配性别、年龄的30名健康人作为对照组。研究组予度洛西汀治疗8周。两组分别在治疗前以及8周后予情绪图片刺激的点探测任务检测,比较治疗前以及8周后反应时以及注意偏向分差别。结果:研究组8周后症状自评量表(SCL-90)躯体化因子分明显低于治疗前(t=3.985,P=0.007)。重复测量ANOVA显示,探测位置主效应显著[F(1,58)=15.40,P=0.038],异侧位置的反应时长于同侧位置;情绪面孔图片类型与组间水平交互作用显著[F(1,58)=19.08,P=0.000];探测位置与组间水平交互作用显著[F(1,58)=18.31,P=0.000];情绪面孔图片类型与探测位置交互作用显著[F(1,58)=13.51,P=0.021];情绪面孔图片类型×探测位置×组间水平交互作用显著[F(1,58)=11.24,P=0.002],LSD比较显示研究组对负性面孔图片异侧位置的反应时长于同侧位置(P=0.001)。研究组治疗8周后对负性面孔图片反应时以及注意偏向分明显低于治疗前(t=2.812、3.531,P=0.018、0.002)。结论:躯体形式障碍患者对负性面孔图片信息表现出认知偏倚,度洛西汀具有改善认知偏倚的作用。Objective: To investigate the effect of duloxetine treatment on cognitive bias to the emotional facial information in patients with somatoform disorder (SD). Method:Thirty patients who met CCMD-3 (chinese classification of mental closorders-3rd edition)criteria for SD were enrolled as research group and 30 sex-and-age-matched healthy persons enrolled as control group.Patients were treated with duloxetine for 8 weeks.All participants measured with dot-probe task of emotional facial information at base and after 8 weeks.Response times(RTs)and attentional bias scores were compared respectively. Results:After 8 weeks,SCL-90 somatization factor scores(SOM) in research group were lower than that of at base(t=3.985,P=0.007).A repeated measure ANOVA revealed a significant probe site main effect [F(1,58)=15.40,P=0.038)],RTs of antarafacial site were longer than that of homonymy site.It revealed a significant emotional facial information type and group interaction[F(1,58)=19.08,P=0.000)],a significant probe site and group interaction [F(1,58)=18.31,P=0.000)],a significant emotional facial information type and probe site interaction [F(1,58)=13.51,P=0.021)],and a significant emotional facial information type × probe site ×group interaction[F(1,58)=11.24,P=0.002)].LSD test showed that RTs of antarafacial site to negative facial information in research group were longer than that of homonymy site(P=0.001).RTs and attention bias scores of antarafacial site to negative facial information after 8 weeks in research group were lower than that of at base (t=2.812,3.531;P=0.018,0.002). Conclusion:Patients with SD have the cognitive bias to the negative facial emotional stimulus.Duloxetine treatment might improve the cognitive bias.

关 键 词:躯体形式障碍 情绪面孔图片 点探测任务 认知偏倚 度洛西汀 

分 类 号:R749.2[医药卫生—神经病学与精神病学]

 

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