躯体形式障碍患者认知功能与事件相关电位P300的研究  

The relationship between cognitive functions and event related potentials P300 in patients with somatoform disorders

作　　者：谢国军[1] 罗伟森[1] 赵长江[1] 李晓玲[1] 黎雪松[1] 

机构地区：[1]广东佛山市第三人民医院,528041

出　　处：《临床精神医学杂志》2013年第2期96-98,共3页Journal of Clinical Psychiatry

基　　金：广东省医学科研基金课题(A2010603)

摘　　要：目的:探讨躯体形式障碍患者的认知功能状况及其与P300的关系。方法:对120例躯体形式障碍患者及60例正常对照组分别进行P300检测和瑞文标准推理测验、数字广度与数字符号测验,并对结果进行比较。结果:躯体形式障碍组的瑞文推理、数字广度、数字符号分数均低于对照组,差异有统计学意义(P<0.01);N1、P2、P3潜伏期较对照组延长,N1N2、N2P2、P2P3波幅低于对照组,差异有统计学意义(P<0.01或P<0.05);瑞文推理分数与N1潜伏期正相关;数字广度分数与P2潜伏期、N2潜伏期正相关,与N1N2波幅负相关;数字符号分数与N1N2波幅、P2P3波幅正相关,与N2P3波幅负相关。结论:躯体形式障碍患者的认知功能缺陷范围较广,不同的P300成分可能反映躯体形式障碍不同类型的认知功能损害。Objective： To investigate the cognitive functions and its relationship with event related potentials P300 in patients with somatoform disorders. Method：120 cases of patients with somatoform disorders and 60 normal controls were examined P300 and the Raven＇s standard progressive matrices test,digit span and digit symbol test of China revised Wechsler adult intelligence scale,and the results were compared. Results：For somatoform disorders,Raven reasoning,digit span,digit symbol scores were significantly lower than the controls（P0.01）;event related potentials N1,P2,P3 latencies were significantly longer than the controls（P0.01 or P0.05）,N1N2,N2P2,P2P3 amplitudes were significantly lower than the controls（P0.01 or P0.05）;Raven reasoning scores were positively correlated with N1 latencys;digit span scores were positively correlated with P2,N2 latencys and negatively correlated with N1N2 amplitudes;digit symbol scores were positively correlated with N1N2,P2P3 amplitudes and negatively correlated with N2P3 amplitudes. Conclusion：The cognitive deficits range is wide,different P300 components may reflect different cognitive impairments in patients with somatoform disorders.

关 键 词：躯体形式障碍 认知功能 事件相关电位P300 

分 类 号：R749.7[医药卫生—神经病学与精神病学]