超早期大剂量尿激酶治疗自发性脑室出血  

Treatment of spontaneous intraventricular hemorrhage with high-dose urokinase in the ultra-early stage

作　　者：董海海[1] 王永和[2] 曹培成[2] 程迎新[2] 

机构地区：[1]潍坊医学院外科学教研室,山东潍坊261053 [2]潍坊市人民医院脑科医院神经外一科

出　　处：《青岛医药卫生》2013年第2期96-98,共3页Qingdao Medical Journal

摘　　要：目的探讨超早期大剂量尿激酶治疗自发性脑室出血的临床疗效。方法将72例自发性脑室出血患者随机分为A组(超早期组)、B组(早期组)、C组(延期组),分别于出血后6～8h、8～72h和72h之后应用尿激酶治疗。3组均行侧脑室外引流加大剂量尿激酶灌注治疗,术后观察治疗并随访1～6个月。结果 1个月后,A组和B组的再出血、感染、继发脑积水率及存活率均优于C组(P<0.05);6个月后,A组日常生活能力(ADL)显著优于B组和C组(P<0.05)。结论超早期大剂量尿激酶灌注治疗自发性脑室出血,可降低术后并发症的发生率,提高患者的存活率和生存质量。Objective To investigate the clinical effect of high-dose urokinase in treating spontaneous intraventricular hemorrhage in the ultra-early stage. Methods After admission,72 cases of spontaneous intraventricular hemorrhage were randomly divided into group A, B and C. The patients in group A were operated by perfusing with high-dose urokinase within 6-8 hours af- ter bleeding, group B more than 8 hours and less than or equal to 72 hours and group C more than 72 hours. Then they were treated with observation and followed up for 1-6 months. Results Af- ter 1 month, the rates of rehaemorrhagia, infection, secondary hydrocephalus and the survival rate of group A and B were better than group C （P〈0.05）. After 6 months,The ADL of group A was significantly better than group B and C （P〈0.05）. Conclusion Ultra-early perfusion therapy with high-dose urokinase can reduce the incidence of postoperative complications of spon- taneous intraventricular hemorrhage and improve the patients＇ survival rate and quality of life.

关 键 词：自发性 脑室出血 超早期 大剂量 尿激酶 

分 类 号：R743.34[医药卫生—神经病学与精神病学]