抗磷脂综合征缺血性卒中23例临床分析  

Clinical Analysis of 23 Patients with Antiphospholipid Syndrome Related Ischemic Stroke

作　　者：郑书恭 杨炼红[2] 刘军[2] 容小明[2] 

机构地区：[1]广东省东莞市大朗医院神经内科,523770 [2]中山大学孙逸仙纪念医院神经内科

出　　处：《岭南急诊医学杂志》2013年第1期26-27,共2页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨抗磷脂抗体综合征(APS)缺血性卒中的临床特点。方法:回顾性分析2003年1月至2011年12月住院治疗的23例APS并缺血性脑卒中患者的临床资料。本组23例中男13例,女10例,平均年龄(37.9±10.9)岁;其中1例表现为TIA,22例为脑梗塞,5例患者既往有脑卒中病史。头颅影像学检查示43.5%为多发脑梗塞。血液学检查示血小板减少12例,所有患者的抗磷脂抗体(aPL)阳性。结果:好转17例(79.3%),2例患者治疗过程中再发脑梗塞。结论:APS缺血性卒中多年轻起病、反复发作,且aPL阳性,持续的抗凝或抗栓治疗可预防卒中再发。Objective： To explore the characteristics of antiphospholipid syndrome （APS） related ischemic stroke. Methods： The clinical data of 23 patients with APS related ischemic stroke were analyzed retrospectively from Jan 2003 to Dec 2011. Among the 23 cases, there were 13 male and 10 female , the mean age was （37.9_＋10.9） years. 1 case suffered from TIA and the other 22 cases were diagnosed as ischemic cerebral stroke（ICS）. 5 of them had ICS history. Imaging tests showed that multiple cerebral infractions happened in 43.5%（10/23） cases. 12 cases were also diagnosed as thrombocytopenia, and all patients were aPL positive. Results： Among the 23 cases, 17（69.3%） cases were effective and new onset ICS happened in 2 cases during the treatment. Conclusions： APS ischemic stroke were young onset and recurrent. Most of them were aPL positive. Anticoagulant or antithrombotic therapy could help to prevent stroke recurrence.

关 键 词：抗磷脂抗体综合征 缺血性卒中 复发 预防 

分 类 号：R743.3[医药卫生—神经病学与精神病学]