超重肥胖与中国女性乳腺癌关系的Meta分析  

A meta-analysis on overweight, obesity and the risk of breast cancer in Chinese female population

作　　者：张琪[1] 钱云[2] 靳子义[3] 董美华[2] 韩仁强[4] 周金意[4] 赵金扣[4] 张作风 武鸣[4] 

机构地区：[1]东南大学公共卫生学院流行病与卫生统计学系,南京210009 [2]无锡市疾病预防控制中心健康促进部 [3]南京医科大学公共卫生学院流行病与卫生统计学系 [4]江苏省疾病预防控制中心慢性非传染病防制所 [5]Department of Epidemiology, UCLA School of PublicHealth, Los Angeles, USA

出　　处：《中华预防医学杂志》2013年第4期358-362,共5页Chinese Journal of Preventive Medicine

摘　　要：目的探讨超重肥胖与中国女性乳腺癌发病风险的关系。方法收集国内外公开发表的关于超重肥胖与中国女性乳腺癌研究的文献，以“乳腺癌”、“超重”、“肥胖”、“体重”、“体质指数”、“体重指数”和“危险因素”为关键词，检索中国知网、万方数据知识服务平台、中文期刊数据库（维普）等中文数据库；以“breastcancer”、“overweight”、“obesity”、“China”、“riskfactors”为关键词，检索荷兰医学文摘（Embase）、PubMed、ScienceDirect、Elsevier、Cochrane等英文数据库并辅以文献追溯等方法，时间范围从各数据库建库至2012年4月，共检索到124篇文献。采用Statal1．2软件进行统计分析，运用Meta分析的方法计算合并OR（95％C1）值。结果最终纳入18篇文献，包括中文12篇，英文6篇，纳人研究的病例7217例，对照81605名。Meta分析的结果表明合并OR（95％CI）值为1．08（1．04-1．12），超重肥胖女性相对正常女性乳腺癌的发病风险增加了7．7％，绝经状态捌整前后超重肥胖女性相对于正常BMI值女性的OR（95％C1）值分别为1．07（1．03-1．11）和1．56（1．29-1．84）。结论超重肥胖是中国女性乳腺癌的重要危险因素之一，有钊‘对性的开展干预将有助于降低女性乳腺癌的人群发病风险。Objective To estimate the association between overweight, obesity and the risk of breast cancer in Chinese female population. Methods Literatures published in China and abroad about overweight,obesity and breast cancer risk among Chinese females were searched. We used ＂breast cancer＂, ＂overweight＂ ,＂ obesity＂ ,＂ weight＂ ,＂body mass index＂ and ＂risk factors＂ as keywords, to retrieve papers in Chinese literature databases including CNKI,Wanfang and Weipu database. The same strategy was used to retrieve English papers in English literature database including Embase database, PubMed, Science Direct, Elsevier and Cochrane database, supplemented by literature tracing method. Time range was from the founding of each database to April 2012. A total of 124 research papers were collected. Using Statall. 2 software, meta-analysis was conducted,combined odds ratio （OR） and 95% confidence interval （CI） were calculated to estimate the associations between overweight, obesity and the risk of breast cancer in Chinese female population. Results Eighteen studies were included in meta-analysis, among them 12 studies were in Chinese and 6 were in English, with a number of 7217 cases and 81 605 controls. Results showed a 7.7% increased risk of breast cancer among overweight or obesity women （OR = 1.08,95% CI： 1.04 - 1.12）. Compared with normal BMI women,the 0R（95% CI） of overweight or obesity women were 1.07 （ 1.03 - 1.11 ） and 1.56 （1.29 - 1.84 ） before and after the adjustment of menopausal status. Conclusion Overweight,obesity may be important risk factors of breast cancer in Chinese temale population. Theintervention and control activities may reduce the risk of breast cancer at population level.

关 键 词：超重 肥胖症 中国 乳腺肿瘤 META分析 

分 类 号：R737.9[医药卫生—肿瘤]