葛根素双层渗透泵控释片的处方优化及体外释药研究  

Study on the formulation optimization and drug release in vitro of two-layer controlled osmotic-pump tablets of puerarin

作　　者：张娥[1] 谭睿[2] 顾健[1] 何黎黎[1] 姚峰[1] 

机构地区：[1]西南民族大学民族医药研究院,四川成都610041 [2]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《华西药学杂志》2013年第2期111-113,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:81173594);四川省科技支撑项目(2011SZ0231);四川省应用基础项目(2012JY0025);成都市科技局项目(11DXYB263JH-027);中央高校基本科研业务费专项资金项目(11NZYTH02)

摘　　要：目的制备葛根素双层渗透泵控释片,考察影响其释药行为的因素。方法调整促渗剂的含量及包衣液的成分,研究单一因素对渗透泵体外释放的影响,并通过均匀设计实验,确定最优处方。结果葛根素双层渗透泵控释片的释药行为受促渗剂、衣膜厚度、致孔剂的影响显著。结论采用最优处方成功制备葛根素双层渗透泵控释片,释放行为符合零级释放特征。OBJECTIVE To prepare two - layer controlled osmotic - pump tablets of puerarin and investigate the drug release in vitro. METHODS The single factor that aft）cted drug release in vitro were investigeted. Then, uniform design was used to optimize the formulation of controlled osmotic - pump tablets. RESULTS Drug release profiles in vitro were obviously affected by membrane thickness, penetrating agents and porogen. CONCLUSION Two - layer controlled osmotic - pump tablets of puerarin were prepared according to the optimal formulation with zero-order kinetics.

关 键 词：葛根素 双层渗透泵控释片 处方优化 体外释药 野葛 

分 类 号：R94[医药卫生—药剂学]