云南美登木的研究进展  

Research Progress of Maytenus Hookerii Loes

作　　者：和静萍[1] 顾健[2] 黄福开[3] 曹雨虹[1] 谭睿[1] 

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031 [2]西南民族大学民族药物研究所,四川成都610051 [3]中国藏学研究中心北京藏医院,北京100029

出　　处：《中华中医药学刊》2013年第4期721-724,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：科技部科技基础性工作专项资助项目(2009FY220100);中央高校基本科研业务费专项资金资助项目(11NZYTH02);中央高校基本科研业务费专项资金资助项目(SWJTU11ZT26)

摘　　要：中药材云南美登木(Maytenus Hookerii Loes.)属卫矛科(Celastraceae)植物,是一种有效的抗癌原料物。1959年研究至今,已从云南美登木组织及其各种菌株中分别提取分离得到了以美登木素、美登普林、美登布丁为主的20余种化学成分,且其提取物在抗肿瘤等方面具有有效剂量小,安全系数大,不良反应小等突出特点。本文就云南美登木的种质资源、化学成分及其相关药理活性、毒性各方面的研究进展进行了综述,为深入研究和综合开发利用云南美登木提供参考。Maytenus Hookerii Loes,which refers to a class of Celastraceae, is a kind of anticancer drug stocks of high efficiency. From its histiocytes and bacterial strains, more than 20 categories of chemical components （ mainly maytansine, maytanprine,maytanbutine, etc. ）have been extracted and separated since the initial research in 1972. Outstanding char- acteristics such as low effective dose with high security coefficient and fewer side - effects have been confirmed in cancer treatments. In short,this paper reviewed and summarized the research achievements of Maytenus Hookerii Loe~ chemical compositions,the pharmacological actions and toxicity, in order to provide reference for Maytenus Hookerii Loes Is futher study, development and application.

关 键 词：云南美登木 化学成分 药理活性 毒性 

分 类 号：R222.19[医药卫生—中医基础理论]