功能性消化不良患者血清胃促生长素水平与焦虑抑郁评分的关系  

The Correlation Between Serum Ghrelin Levels and Score of Anxiety and Depression in Patients With Functional Dyspepsia

作　　者：曾跃飞[1] 吴青[1] 

机构地区：[1]南华大学附属南华医院消化内科,湖南衡阳421002

出　　处：《中南医学科学杂志》2013年第2期168-170,共3页Medical Science Journal of Central South China

摘　　要：目的探讨功能性消化不良(FD)患者血清胃促生长素(Ghrelin)水平与焦虑抑郁评分的关系。方法采用ELISA法测定42例功能性消化不良患者和42例健康体检人群(对照组)空腹血清Ghrelin水平,以焦虑自测量表(SAS)和抑郁自测量表(SDS)对两组人群进行焦虑抑郁评分。结果功能性消化不良患者血清Gh-relin水平显著低于对照组(P<0.01),功能性消化不良患者SAS和SDS评分均显著高于对照组(P<0.01),血清Ghrelin水平与SAS和SDS评分均呈负相关(r=-0.68,P<0.01;r=-0.63,P<0.01)。结论功能性消化不良患者血清Ghrelin水平与焦虑、抑郁评分呈负相关。Objective To investigate the correlation between serum Ghrelin levels and score of anxiety and depression in patients with functional dyspepsia. Methods Serum Ghrelin levels of 42 cases of patients with functional dyspepsia and 42 cases of healthy people were measured by ELISA. Self-rating anxiety scale （ SAS ） and self-rating depression scale （ SDS ） were used to score anxiety and depression of the two groups. Results Serum Ghrefin levels of patients with functional dyspepsia were significantly lower than the control group（ P 〈 0.01 ） , anxiety and depression scores in patients with functional dyspepsia were significantly higher than those in the control group （ P 〈 0.01 ）, a negative correlation （ r = - 0.68,P 〈 0.01 ;r = -0. 63,P 〈0.01 ） has been identified among the Scores for SDS,SAS and serum Ghrelin levels. Conclusion Serum Ghrelin levels and score of anxiety and depression has a negative correlation in patients with functional dyspepsia.

关 键 词：功能性消化不良 胃促生长素 焦虑 抑郁 

分 类 号：R57[医药卫生—消化系统]