叶酸和维生素B_(12)、B_6对阿尔茨海默症患者血浆Hcy、血脂水平的影响  

Effects of folic acid and vitamin B12 and B6 on levels of Hcy and lipids in blood from patients with Alzheimer's disease

作　　者：张克明[1] 雷雯[1] 职心乐[2] 刘欢[2] 黄国伟[2] 

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]天津医科大学公共卫生学院

出　　处：《山东医药》2013年第15期20-22,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(81130053)

摘　　要：目的观察叶酸和维生素B12、B6对阿尔茨海默症患者血浆同型半胱氨酸(Hcy)、血脂水平的影响。方法选择阿尔茨海默症患者42例,随机分为干预组和对照组,各21例。两组常规治疗相同,干预组同时服用叶酸和维生素B12、B6,均治疗30 d。治疗前后检测两组血浆Hcy、D-二聚体(D-D)、纤维蛋白原(FIB)和血脂,并进行长谷川痴呆量表(HDS)评分。结果干预组治疗后血浆Hcy、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(LDL-V)、D-D、FIB下降水平高于对照组(P均<0.05),HDS评分高于对照组(P<0.05)。结论补充叶酸和维生素B12、B6可降低阿尔茨海默症患者血浆Hcy和血脂水平。Objects To observe the effects of folic acid and vitamin B12 and B6 on the levels of Hcy and blood lipids in Alzheimer＇s disease patients. Methods In this study, 42 cases of patients with Alzheimer＇s disease were selected. They were divided into intervention group （21 cases） and control group （21 cases） randomly. Regular treatment was con- ducted in both groups for 30 days, meanwhile, folic acid and Vitamin Bi2, B6 treatment for intervention group. Hcy, D-D, FIB, blood lipid levels and HDS evaluation of pre-treatment and post-treatment were compared between two groups. Results The levels of Hcy, TC, TG, LDL-C, LDL-V, D-D and FIB decreased more significantly in intervention group than in control group（ all P 〈 0.05）. While the HDS evaluation showed better in intervention group after the intervention treatment （ P 〈 0.05 ）. Conclusion This study suggests that treatment of folic acid and Vitamin B12 and B6 has the effects of decrea- sing Hcy and blood lipids levels in patients with Alzheimer＇s disease.

关 键 词：叶酸 维生素B12 维生素B6 阿尔茨海默症 同型半胱氨酸 血脂 

分 类 号：R742[医药卫生—神经病学与精神病学]