73例非小细胞肺癌脉管癌栓临床分析  

Clinical analysis of 73 non-small cell lung cancer patients with vessel invasion

作　　者：刘毅[1] 初向阳[1] 薛志强[1] 马克峰[1] 

机构地区：[1]解放军总医院胸外科,北京100853

出　　处：《解放军医学院学报》2013年第4期322-324,共3页Academic Journal of Chinese PLA Medical School

摘　　要：目的探讨非小细胞肺癌脉管癌栓对术后肺癌病人的影响。方法以2006年1月-2010年12月期间就诊我院胸外科73例存在脉管癌栓的非小细胞肺癌切除术后患者病例为实验组行回顾分析,并以同时期、同TNM分期及同病理类型无脉管癌栓患者219例为对照组,用Kaplan-Meier方法分析其生存期及无复发生存期,用COX比例危险模型行单因素及多因素分析。结果单因素分析肺癌脉管癌栓对术后生存影响的危险度为1.890;实验组的1、3、5年累计生存率分别为90.32%,49.77%,24.89%,小于对照组生存率(P=0.009,B=9.983);实验组1、3、5年无复发生存率分别为69.44%、55.32%,55.32%,小于对照组(P=0.000,B=23.85)。结论脉管癌栓是影响肺癌患者术后生存期及术后复发和转移的重要因素。Objective To study the effect of vascular invasion on non-small lung cancer（NSLC） patients after surgery.Methods 73 NSCLC patients with vessel invasion who underwent surgical operation in our department from January 2006 to December 2010 served as an experimental group,and 219 NSCLC patients without vessel invasion served as a control group in this study.Their clinical data were retrospectively analyzed.Their 1-,3-,5-year survival rates and relapse-free survival rates were calculated using the Kaplan-Meier method and analyzed by Univariate and multivariate analysis according to the Cox risk model.Results Univariate analysis showed that the risk for the survival of NSCLC patients with vascular invasion after operation was 1.890.The 1-,3-,5year survival rates of experimental group were 90.32%,49.77%,24.89% respectively,which were lower than those of control group（P=0.009,B=9.983）.The 1-,3-,5-years relapse-free survival rates of experimental group were 69.44%,55.32%,55.32% respectively,which were also lower than those in control group（P=0.000,B=23.85）.Conclusion Vessel invasion is an important factor that influences survival,recurrence and metastasis of NSCLC after operation.

关 键 词：癌 非小细胞肺 手术 脉管癌栓 生存期 

分 类 号：R734.2[医药卫生—肿瘤]