艾司西酞普兰与帕罗西汀治疗强迫症的临床疗效研究  

A comparative study of the clinical efficiency of escitalopram and paroxetine in treatment of obsessive-compulsive disorder

作　　者：陈曲亮[1] 翁客华[1] 王俊清[1] 许振强[1] 王兴隆[1] 

机构地区：[1]汕头大学精神卫生中心,汕头515041

出　　处：《中华行为医学与脑科学杂志》2013年第3期196-198,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：广东省医学科研基金资助项目（A2012409）

摘　　要：目的比较艾司西酞普兰与帕罗西汀治疗强迫症临床疗效与安全性的差异。方法将165例符合中国精神障碍分类与诊断标准第三版（CCMD一3）强迫症患者，按随机数字表法分为艾司西酞普兰治疗组（ESC组）和帕罗西汀治疗组（PAR组），采用耶鲁一布朗强迫症状量表（Yale—Brown Obsessive Compulsive Scale，Y—BOCS）、汉密尔顿抑郁量表（HAMD）和不良反应量表（TESS）分别在治疗前和治疗后第1，2，4，6，8周末评估其疗效和安全性。结果ESC组和PAR组痊愈率（21．79％，17．95％）、有效率（70．51％，71．79％）差异无统计学意义（P〉0．05），不良反应事件发生率差异无统计学意义（χ^2=1．99，P〉0．05）；与治疗前比较，ESC组自第1周末HAMD量表评分明显降低，PAR组自第2周末HAMD量表评分才明显降低，差异有统计学意义（P〈0．05）。结论艾司西酞普兰对强迫症患者临床疗效确切，起效快，药物耐受性好，安全性高。Objective To investigate the difference of clinical efficiency and safety in obsessive-compulsive disorders （OCD） treatment with escitalopram or paroxetine. Methods A total of 156 OCD patients were randomly divided into escitalopram group （ ESC group ） and paroxetine group （ PAR group ）. Yale-Brown Obsessive Compulsive Scale （Y- BOCS ）, Hamilton Depression Scale （HAMD） and Treatment Emergent Symptom Scale （TESS） were used to evaluate the clinical efficiency and safety before and afterl, 2,4,6,8 weeks treatment. Resuits The cure rate（21.79% vs 17.95% ） and effective rate（70.51% vs 71.79% ） had no statistically difference between ESC group and PAR group, and incidence of side effect had no significant difference between two groups（χ^2 = 1.99, P 〉 0.05 ）. Compared with the group before treatment, HAMD scores were significantly decreased from the first weekend in ESC group, but in PAR group HAMD scores did not decrease until the second weekend, and the differences were also significant（P 〈 0.05 ）. Conclusion Escitalopram is a safety, effective and well-tolerated drug in the treatment of obsessive-compulsive disorder.

关 键 词：艾司西酞普兰 帕罗西汀 强迫症 临床疗效 安全性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]