托吡酯与卡马西平治疗脑梗死后继发癫痫临床疗效差异  

Difference of clinical efficacy of topiramate and carbamazepine in the treatment of cerebral infarction with secondary epilepsy

作　　者：卢颖瑜[1] 江锦霞[2] 王鹏[1] 周庆昆[1] 黄秉文[1] 

机构地区：[1]佛山市第二人民医院,广东佛山528000 [2]深圳市龙岗中心医院,广东深圳518116

出　　处：《中外医疗》2013年第8期3-3,5,共2页China & Foreign Medical Treatment

摘　　要：目的探讨托吡酯与卡马西平治疗脑梗死后继发癫痫临床疗效差异。方法选择2010年4月—2012年4月脑梗死后继发癫痫60例,随机分观察组和对照组。两组除常规治疗外,对照组给予卡马西平,观察组给予托吡酯治疗。治疗24周后评定疗效。结果观察组总有效率和对照组总有效率分别为96.7%和70.0%,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论托吡酯治疗脑梗死后继发癫痫疗效显著,优于卡马西平,值得借鉴。Objective To explore the difference of clinical efficacy of topiramate and carbamazepine in the treatment of cerebral infarction with secondary epilepsy. Methods 60 cases with epilepsy after cerebral infarction were selected from april 2010 to april,2012, and they were randomly divided into observation group and control group, topiramate was given to observation group. the course was 24 weeks, after 24 weeks, clinical efficacy was evaluated in two groups. Results The total effective rate in the ob- servation group was 96.7%,the total effective rate in the control group was 70.0%,the total effective rate in the observation group compared with that in control group, the total effective rate in the observation group was higher than that in control group-,the dif- ference was statistically significant（P〈0.05）. Conclusion Topiramate in treatment of cerebral infarction with secondary epilepsy has significantly clinical efficacy, and which is superior to carbamazepine.

关 键 词：脑梗死后继发癫痫 托吡酯 卡马西平 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]