手性医药化学品生物催化合成进展与实践  

Biocatalysis and green process for chiral pharmaceutical chemicals

作　　者：郑裕国[1] 沈寅初[1] 

机构地区：[1]浙江工业大学生物工程研究所生物转化与生物净化教育部工程研究中心,杭州310014

出　　处：《生物加工过程》2013年第2期24-29,共6页Chinese Journal of Bioprocess Engineering

基　　金：国家高技术研究发展计划(863计划)(2012AA022201)

摘　　要：手性生物催化是利用生物催化剂对手性分子构型的识别能力进行选择性催化的新型物质加工过程,具有催化效率高、选择性强和反应条件温和等优势。近十年来,生物催化技术快速崛起,树立了多个大品种原料药过程替代的成功范例,成为手性医药化学品绿色制造不可或缺的重要工具。笔者分析了生物催化商业和学术发展的新动向,并结合笔者在手性药物生物催化合成的产业化开发实践,指出了今后的发展方向。Enantioselective biocatalysis is a modem material processing technology based on the recognition capability of bioeatalyst to ehiral molecular configuration, it had major advantages of high efficiency, high selectivity and ambient reaction conditions. In the last 10 years, rapid advances in largescale DNA sequencing and enzyme directed evolution rendered biocatalysis as necessary synthetic tool in green pharmaceutical process. Several successful examples were given and a biocatalytic process was developed to replace existing chemical routes for blockbuster drugs. Advances in synthesis of chiral pharmaceutical chemicals by biocatalysis were analyzed combined with research experiences in recent years and development directions of the area were pointed out.

关 键 词：手性药物 生物催化 酶工程 绿色制药 

分 类 号：TQ46[化学工程—制药化工]