人胃癌中端粒酶活性表达的研究  

Expression of Telomerase in Human Gastric Carcinoma

作　　者：王力 马艳[2] 吴成秋 陈临溪 

机构地区：[1]衡阳市中心医院普外科,湖南衡阳421001 [2]衡阳医学院附一医院妇产科 [3]衡阳医学院卫生学教研室 [4]衡阳医学院药理学教研室

出　　处：《衡阳医学院学报》2000年第4期348-350,共3页

摘　　要：目的　探讨人胃癌组织中端粒酶的活性表达。方法　采用端粒重复序列扩增法 (temolericrepeatamplificationprotocol,TRAP)检测 4 2例原发性胃癌及相应的癌旁组织中端粒酶活性。结果　在 4 2例胃癌中 ,有 35例端粒酶呈阳性 ,而癌旁组织中仅有 2例阳性。结论　端粒酶激活与胃癌的发生有关 。Objective:To investigate telomerase expression in human gastric carcinoma.Method:Telomerase activity in 42 primary gastric carcinomas and tumor adjacent tissues was detected by telomeric repeat complification protocol(TRAP).Result:35 out of 42 (83.33%) tumor samples exhibited telomerase activity.However,telomerase activity in the tumor-adjacent tissues was detected only in 2 of 42 specimens(4.76%).Conclusion:Telomerase expression might contribute to the generation of gastric carcinoma and could be used as the tumor marker of gastric carcinoma.

关 键 词：胃肿瘤 端粒酶 聚合酶链反应 

分 类 号：R735.202[医药卫生—肿瘤]