高海拔地区进展期胃癌患者手术前后T细胞亚群的变化  

CHANGES OF T CELL SUBGROUP BEFORE AND AFTER GASTRECTOMY FOR CANCER IN PATIENTS WITH ADVANCED GASTRIC CACINOMA AT HIGH ALTITUDE

作　　者：王见[1] 

机构地区：[1]青海省人民医院肿瘤外科,810007

出　　处：《高原医学杂志》2000年第2期42-43,共2页Journal of High Altitude Medicine

摘　　要：目的 :观察高海拔地区进展期胃癌 (AGC)患者手术前后T细胞亚群的变化 ;方法 :采用间接免疫荧光法对 3 2例进展期胃癌患者手术前后不同时期的T细胞亚群进行检测 ;结果 :①高海拔地区进展期胃癌患者CD3、CD4、CD8、CD4/CD8值均低于正常对照组。②根治性切除术后 ,患者的CD3、CD4细胞值较术前有显著性差异 (P <0 .0 1) ;CD4/CD8细胞比值亦较术前有显著性差异 (P <0 .0 1) ,但与正常对照组之间无显著性差异 (P >0 .0 5 ) ;结论 :高海拔地区进展期胃癌患者免疫功能低下 ,T细胞功能受到抑制 ;胃癌根治性切除术后 ,可改善患者的免疫功能。To observe changes of T cell subgroup in patients with gastric carcinoma at high altitude.Methods:T cell subgroups were examined before and after gastrectomy in 32 cases with advanced gastric carcinoma by indirect immunofluoscence.Results:CD 3,CD 4,CD 8 and CD 4 to CD 8 radio in the patients with advanced gastric carcinoma were lower than that in control; And these cell numbers arised markably (P<0.01) after gastrectomy for cancer,but CD 4/CD 8 was low compared with control.Conclusion:The immunologic function could be improved in patients with advanced gastric carcimnoma by gastrectomy at high altitude.

关 键 词：高海拔地区 胃肿瘤 T淋巴细胞亚群 治疗 

分 类 号：R735.2[医药卫生—肿瘤]