P2X7受体在炎症性疾病中的作用及其机制  

Effect of P2X7 receptor on inflammatory diseases and its mechanism

作　　者：徐宏[1] 梁尚栋[1] 

机构地区：[1]南昌大学基础医学院生理学教研室,南昌330006

出　　处：《生理学报》2013年第2期244-252,共9页Acta Physiologica Sinica

基　　金：supported by the grants from the National Natural Science Foundation of China(No.30860086;31060139and81171184);the Technology Pedestal and Society Development Project of Jiangxi Province;China(No.2010BSA09500);the Young Scholars Science Foundation of Jiangxi Province;China(No.20122BAB215005);the Youth Science Foundation of the Education Department of Jiangxi Province;China(No.GJJ12149)

摘　　要：P2X7受体是以三磷酸腺苷（ATP）为配体的非选择性阳离子门控通道。P2X7受体在体内分布极为广泛，在多种炎性病理状态下表达上调。与P2X受体家族其它成员（P2X1-6）不同，长时间或高浓度激动剂激活后P2X7受体具有形成膜孔的特性，可诱导炎症介质的释放，这种特性与多种炎症性疾病密切相关。近年来，随着基因敲除P2X7受体的动物模型和特异性P2X7受体拮抗剂在炎症性疾病研究的广泛运用，P2X7受体可望成为炎症性疾病治疗的新靶点。本文对P2X7受体在炎症性疾病中的作用及其机制的研究进展作一综述。P2X7 receptor is a member of ATP-gated non-selective cation channels. P2X7 receptor is widely distributed in vivo, and its expression is always observed to be up-regulated in the pathological inflammatory circumstances. P2X7 receptor has an unusual prop- erty of forming membrane pore during prolonged agonist exposure or high concentrations of agonist activation, different from other members of P2X receptors （P2X1-6）. Because of this property, P2X7 receptor has been implicated in inflammatory cytokine release, and is closely related to inflammatory diseases. With the wide application of the P2X7-knockout animal model and specific P2X7 receptor antagonists in inflammatory disease research, P2X7 receptor is emerging as a new target for the treatment of inflammatory diseases. This article will review the recent progress regarding the effect of P2X7 receptor on inflammatory diseases and its mecha- nism.

关 键 词：嘌呤2X7受体 三磷酸腺苷 炎症性疾病 白细胞介素-1Β 白细胞介素-18 

分 类 号：R363[医药卫生—病理学]