解郁颗粒合并帕罗西汀治疗阴虚内热型难治性抑郁症的疗效观察  

Treatment of Refractory Depression Patients of Yin Deficiency Inner Heat Syndrome by Jieyu Granule Combined Paroxetine: an Efficacy Observation

作　　者：刘杰[1] 贾竑晓[1] 王建琴[1] 许英[1] 田金洲[2] 时晶[2] 

机构地区：[1]首都医科大学附属北京安定医院中医科,北京100088 [2]北京中医药大学东直门医院老年科,北京100700

出　　处：《中国中西医结合杂志》2013年第4期462-465,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市中医药科技发展基金项目(No.JJ2005-16);北京市科委研发攻关项目(No.D10110704780000);北京市中医药科技项目(No.JJ2011-09)

摘　　要：目的探讨解郁颗粒合并帕罗西汀治疗阴虚内热型难治性抑郁症的疗效。方法将70例阴虚内热型难治性抑郁症患者随机分为研究组(解郁颗粒合并帕罗西汀治疗)和对照组(中药安慰剂合并帕罗西汀治疗),每组35例,在治疗前及治疗的2、4、8周末分别采用汉密尔顿抑郁量表、汉密尔顿焦虑量表等评分。结果研究组完成32例,脱落3例;对照组完成33例,脱落2例。研究组8周末汉密尔顿抑郁量表总分(14.75±7.85)低于对照组(19.06±8.31,P<0.05),汉密尔顿焦虑量表评分2、4、8周末(17.03±4.25、14.50±5.13、11.03±4.88)低于对照组(19.60±3.96、17.12±4.14、14.64±4.47,P<0.05,P<0.01)。结论解郁颗粒合用帕罗西汀治疗阴虚内热型难治性抑郁症的疗效优于单用帕罗西汀。Objective To explore the efficacy of Jieyu Granule （JG） combined Paroxetine in treating refractory depression （RD） patients of yin deficiency inner heat syndrome （YDIHS）. Methods Seventy RD patients of YDIHS were randomly assigned to the experimental group （JG combined Paroxetine） and the control group （Chinese medical placebo combined Paroxetine）, 35 cases in each group. Hamilt Depression Rating Scale and Hamilton Anxiety Scale were used before treatment, and at the weekend of the 2nd, 4th, and 8th week, respectively. Results In the experimental group, 32 patients completed the trial and 3 patients dropped out. In the control group, 33 patients completed the trial and 2 patients dropped out. At the end of the 8th week of the treatment, the total score of Hamilt Depression Rating Scale was （14.75±7.85） in the experimental group, lower than that of the control group （19.06±8.31, P0.05）. At the end of the 2nd, 4th, and 8th week of the treatment, the score of Hamilton Anxiety Scale was 17.03±4.25, 14.50±5.13, and 11.03±4.88, respectively in the experimental group, lower than that of the control group at each corresponding time point （19.60±3.96, 17.12±4.14, 14.64±4.47, P0.05, P0.01）. Conclusion The efficacy of JG combined Paroxetine for treating RD patients of YDIHS was superior to that of using Paroxetine alone.

关 键 词：难治性抑郁症 解郁颗粒 帕罗西汀 阴虚内热型 

分 类 号：R749.4[医药卫生—神经病学与精神病学]