心脏疲劳家兔实验模式的初步研究  

Preliminary Study of Rabbit Experiment Modality for Evaluating Cardiac Fatigue

作　　者：严小波[1] 罗麟梅[1] 刘磊矗[1] 肖守中[2] 邓溯源[1] 向玲丽[1] 张聪[1] 

机构地区：[1]重庆大学体育学院,重庆400044 [2]重庆博精医学信息研究所,重庆400044

出　　处：《生物医学工程学杂志》2013年第2期287-291,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30270377)

摘　　要：单独应用生物化学指标如肌钙蛋白等难于区分运动诱发的心脏疲劳(EICF)和运动诱发的心肌损伤(EICD),需要增加新指标进行心脏疲劳的综合评估。进行家兔力竭游泳中加入心脏功能变化新指标实验模式的研究,以便为后续心脏疲劳的综合评估的研究提供基础。选用新西兰白兔进行多轮负重游泳实验,达到力竭状态,观察运动应激后第1心音对第2心音幅值比值(S1/S2)和心率(HR)的变化趋势以及24h后是否能恢复。实验中,S1/S2和HR在运动应激初期上升,在力竭状态时下降,24h后能恢复。负荷过重的实验导致3只实验动物死亡,观察到负荷过重和死亡前的一些新现象。用新西兰白兔多轮负重游泳实验模式有助于观察和研究心脏疲劳现象和心脏性死亡先兆。This paper presents a preliminary study of rabbit experiment modality incorporating a new indicator for e- valuating cardiac function changes, providing a basis for subsequent study of cardiac fatigue. Using only biochemical indicators, such as troponins, is difficult to make a distinction between exercise-induced cardiac fatigue （EICF） and exercise-induced cardiac damage （EICD）. Therefore, some new indicators are needed to evaluate cardiac fatigue syn- thetically. In our study, we used New Zealand white rabbits to conduct a multi-step swimming experiments with load. We made the rabbits reach an exhaustive state to evaluate whether the amplitude ratio of the first to second heart sound （$1/$2） and heart rate （HR） during the exhaustive exercise would be decreased and whether they would be able to recover after the exhaustive exercise for 24hours. During the first phase of swimming, S1/S2 and HR were increased, and then decreased at exhaustive state. They were recovered after the exhaustive exercise for 24 hours. O verloading led to deaths of three rabbis, and new phenomena from overloading and related to this kind of death were observed. The experiments proved that Multi-steps swimming experiments with loads by using New Zealand white rabbit is useful for studying cardiac fatigue and premonition of sudden cardiac death,

关 键 词：心脏疲劳 心脏性死亡 实验模式 第1心音对第2心音幅值比值 

分 类 号：R-332[医药卫生]