乳腺浸润性导管癌分子分型与临床特征的关系  

Correlation between Molecular Subtypes and Clinical Features in Invasive Ductal Carcinoma of Breast

作　　者：李庆霞[1] 邢雅军[1] 赵静[1] 颜聪亚[1] 张秀智[1] 荀文娟[1] 

机构地区：[1]河北省人民医院肿瘤一科,石家庄050051

出　　处：《肿瘤防治研究》2013年第4期341-344,共4页Cancer Research on Prevention and Treatment

基　　金：河北省科技支撑计划资助项目(11276103D-70)

摘　　要：目的探讨乳腺浸润性导管癌不同分子亚型的分布,并分析各分子亚型与临床特征的关系。方法收集2006年1月-2011年6月明确诊断为乳腺浸润性导管癌病例100例,根据雌激素受体(ER)、孕激素受体(PR)、表皮生长因子受体-2(HER-2)的表达情况划分为四型,进一步分析不同分子亚型与浸润性导管癌临床特征的关系。结果 100例中Luminal A型所占比例最大为65%,7%为Luminal B型,Triple Negative型占17%,Her-2(+)型占11%。各分子亚型乳腺浸润性导管癌患者发病年龄主要集中在40～59岁之间,占73%,Luminal A型发病年龄主要集中在40～49岁,而其他三型主要分布于50～59岁,四型在不同年龄组的分布上差异有统计学意义(P<0.05);Luminal A型淋巴转移发生率仅为30.1%,而Luminal B型与Her-2(+)型淋巴转移发生率较高,分别为71.4%及63.6%,各分子亚型的腋窝淋巴结转移率有显著差异(P<0.05);病理组织学分级Ⅰ级中Luminal A型所占比例最高,而Tri-ple Negative型主要以Ⅲ级为主,差异具有统计学意义(P<0.05)。结论乳腺浸润性导管癌各分子亚型分布差异具有统计学意义,各分子亚型与其临床特征关系密切。Objective To investigate the distribution of different molecular subtypes of invasive ductal carcinoma of breast（IDC）,and analyze the correlation between molecular subtypes and clinical features.Methods A total of 100 patients with IDC from January 2006 to June 2011 were classified into four different subtypes according to estrogen receptor（ER）,progestogen receptor（PR） and epidermal growth factor-2（HER-2）,and analyze their relation to the clinical features of IDC.Results Among all 100 cases,Luminal A subtype was the majority（65%）,triple negative was the second largest group（17%）,and Her-2 enriched and Luminal B type are the smallest groupes（17% and 7%,respectively）.The ages of patients of IDC subtype were mainly between 40 and 59（73%）.The ages of patients of Luminal A subtype were mainly between 40 and 49.The ages of the patients of the other three molecular subtypes were mainly between 50 and 59（P0.05）.The distributions in different age groups had statistic significance（P0.05）.There were more lymph nodes metastasis in Luminal B（71.4%） and HER-2 enriched（63.6%） groups（P0.05） than in Luminal A group（30.1%）.The axillary lymph nodes metastasis rates of different molecular subtypes varied significantly（P0.05）.As for histopathologic grading,Luminal A patients were mainly gradeⅠ,and most Triple Negative patients were grade Ⅲ（P0.05）.The difference had statistic significance（P0.05）.Conclusion The distributions of different molecular subtypes of IDC has significant difference.The molecular subtypes are related to the clinical features of IDC.

关 键 词：乳腺浸润性导管癌 分子分型 临床特征 

分 类 号：R737.9[医药卫生—肿瘤]