miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases  被引量:6

肥胖与体重正常的前列腺癌患者中miR-21,miR-221与miR.222表达与前列腺癌复发的关系

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作  者:Ernest K Amankwah Evelyn Anegbe Hyun Park Julio Pow-Sang Ardeshir Hakam Jong Y Park 

机构地区:[1]Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA [2]Department of G U Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA [3]Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA

出  处:《Asian Journal of Andrology》2013年第2期226-230,I0007,共6页亚洲男性学杂志(英文版)

摘  要:Recent evidence shows that certain microRNAs (miRNAs) play a role in both obesity and prostate cancer recurrence, but the association between the expression of these miRNAs and obesity in prostate cancer recurrence is unknown. In this study, we examined the effect of the interaction between obesity and miR-21, miR-221 or miR-222 expression on prostate cancer recurrence among 28 recurrent and 37 non-recurrent prostate cancer cases, miRNA expression was determined using quantitative real-time polymerase chain reaction. Cox proportional hazard models adjusting for age at diagnosis, clinical stage and Gleason score were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for recurrence free survival. A significantly (P=0.014) higher proportion of recurrent cases (78,6%) than non-recurrent cases (48.6%) had a low expression of miR-21 and the difference was more prominent in obese than non-obese patients. Multivariate analysis showed that the expression of miR-21 was an independent risk factor for recurrence in obese (HR=6.15, 95% CI= 1.04-36.48, P=-0.045), but not in non-obese (HR= 1.28, 95% C1=0.30-5.49, P=0.74) cases. A significant association with recurrence was not observed for the expression of miR-221 and miR-222. In summary, our findings show that miR-21 is associated with prostate cancer recurrence after radical prostatectomy and suggest that the differential expression of miR-21 is more prominent in obese than in non-obese cases. Future larger studies are warranted to confirm these initial findings and to elucidate the mechanisms involved.Recent evidence shows that certain microRNAs (miRNAs) play a role in both obesity and prostate cancer recurrence, but the association between the expression of these miRNAs and obesity in prostate cancer recurrence is unknown. In this study, we examined the effect of the interaction between obesity and miR-21, miR-221 or miR-222 expression on prostate cancer recurrence among 28 recurrent and 37 non-recurrent prostate cancer cases, miRNA expression was determined using quantitative real-time polymerase chain reaction. Cox proportional hazard models adjusting for age at diagnosis, clinical stage and Gleason score were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for recurrence free survival. A significantly (P=0.014) higher proportion of recurrent cases (78,6%) than non-recurrent cases (48.6%) had a low expression of miR-21 and the difference was more prominent in obese than non-obese patients. Multivariate analysis showed that the expression of miR-21 was an independent risk factor for recurrence in obese (HR=6.15, 95% CI= 1.04-36.48, P=-0.045), but not in non-obese (HR= 1.28, 95% C1=0.30-5.49, P=0.74) cases. A significant association with recurrence was not observed for the expression of miR-221 and miR-222. In summary, our findings show that miR-21 is associated with prostate cancer recurrence after radical prostatectomy and suggest that the differential expression of miR-21 is more prominent in obese than in non-obese cases. Future larger studies are warranted to confirm these initial findings and to elucidate the mechanisms involved.

关 键 词:MIR-21 MIR-221 MIR-222 miRNA obesity prostate carcinoma RECURRENCE 

分 类 号:R[医药卫生]

 

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