狂犬病病毒糖蛋白的抗原性和致病性功能研究进展  

Progress in functional research on antigenicity and pathogenicity of Rabies virus glycoprotein

作　　者：何健[1,2] 张海林[2] 

机构地区：[1]大理学院公共卫生学院,云南大理671000 [2]云南省地方病防治所/云南省病毒立克次体研究中心,云南大理671000

出　　处：《中国媒介生物学及控制杂志》2013年第2期178-182,共5页Chinese Journal of Vector Biology and Control

基　　金：国家自然科学基金(30560142)~~

摘　　要：狂犬病病毒糖蛋白(GP)的抗原性和致病性研究有助于阐明病毒的免疫应答特点和致病机制,从而为狂犬病的有效防治提供科学依据。GP的抗原性不仅用于各种单克隆抗体、基因工程抗体以及新型疫苗的研究,还可辅助病毒感染的早期诊断和暴露后的早期治疗;而病毒的致病性与GP的表达水平及诱导细胞凋亡的能力有紧密联系。因此,GP的抗原性和致病性已逐渐成为人们的研究热点。该文就狂犬病病毒GP的抗原性和致病性最新研究进展予以综述。The study on the antigenicity and pathogenicity of rabies virus （RV） glycoprotein （RVG） is helpful for clarifying the characteristics of immune response to RV and the pathogenesis of rabies, thus providing a scientific basis for effective prevention and treatment of rabies. The antigenicity of RVG is not only utilized in the research on various monoclonal antibodies, genetic engineering antibodies, and new rabies vaccine, but also aids in early diagnosis of RV infection and early treatment after RV exposure. On the other hand, the pathogenicity of RVG is closely related to the expression level of RVG and its ability to induce cell apoptosis. Consequently, the antigenicity and pathogenicity of RVG have gradually become major foci of research. The purpose of this paper is to review the recent progress in the research on the antigenicitv and pathogenicity of RVG.

关 键 词：狂犬病病毒 糖蛋白 抗原性 致病性 狂犬病疫苗 

分 类 号：R512.99[医药卫生—内科学]