Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital  

作　　者：Hailiang Tang Huaping Sun Hong Chen Ye Gong Ying Mao Qing Xie Liqian Xie Mingzhe Zheng Daijun Wang Hongda Zhu Xiaoming Che Ping Zhong Kang Zheng Shiqi Li Weimin Bao Jianhong Zhu Xuanchun Wang Xiaoyuan Feng Xiancheng Chen Liangfu Zhou 

机构地区：[1]Neurosurgery Department of Huashan Hospital [2]Radiology Department of Huashan Hospital [3]Neuropathology Department of Huashan Hospital [4]Endocrinology Department of Huashan Hospital

出　　处：《Chinese Journal of Cancer Research》2013年第1期112-118,共7页中国癌症研究（英文版）

基　　金：supported by National Natural Science Foundation of China(81200936,30872675,30901549);Shanghai Committee of Science and Technology (12JC1401800);2011 Shanghai Medical College Young Scientist Fund of Fudan University(11L-24)

摘　　要：Objective： Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods： 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results： Among the 15 cases （10 males and 5 females）, the age ranged from 22 to 74 years old （the mean age was 50.67-year old）. The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions： Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients.Objective： Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods： 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results： Among the 15 cases （10 males and 5 females）, the age ranged from 22 to 74 years old （the mean age was 50.67-year old）. The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions： Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients.

关 键 词：Metaplastic meningioma FOLLOW-UP mesenchymal differentiation 

分 类 号：R739.45[医药卫生—肿瘤]