促/抑炎因子平衡在反复胚胎种植失败中的作用  

Effect of pro-inflammatory and anti-inflammatory cytokine balance on recurrent implantation failure

作　　者：梁佩燕[1,2] 李观贵 连若纯 陈晓燕 曾勇 

机构地区：[1]北京大学深圳研究生院,广东深圳518000 [2]深圳中山泌尿外科医院 复发性流产与反复胚胎种植失败诊疗中心,广东深圳518000

出　　处：《生殖医学杂志》2013年第4期237-241,共5页Journal of Reproductive Medicine

基　　金：广东省医学科学技术研究基金(B2012331)

摘　　要：体外受精-胚胎移植（IVF—ET）是临床治疗不孕症的主要手段。目前IVF-ET单个周期的妊娠率在50％左右，累计妊娠率已达80％左右，但排除高龄、生殖系统畸形、遗传等因素后仍有10％左右的女性患者经过多个周期治疗未能成功妊娠，通常归为反复种植失败（RIF）。目前RIF的定义是指经历2～6个取卵周期，移植的优质胚胎数目大于10个，The balance of pro-inflammatory and anti-inflammatory cytokine plays a significant role on the process of embryo implantation and pregnancy. However, the imbalance of these cytokines is probably one of the most important causes of recurrent implantation failure. On one hand, the higher pro- inflammatory cytokine or insufficient anti-inflammatory cytokine may activate the immune cells（NK cell, macrophage and T cell）at the fetal-maternal interface, which probably attacks the trophoblast cells and r promotes the formation of thrombus in the villous vessels,thus leads to the immunological rejection to the fetus, implantation failure, early pregnant loss and contributes to the pregnancy complication such as intrauterine growth retardation, preeclampsia and preterm labor. On the other hand, lower pro- inflammatory cytokine or higher anti-inflammatory cytokine may influence the embryo adhesion to endometrium and angiogenesis, which results in implantation failure, In conclusion, the bias of the pro- inflammatory or anti-inflammatory cytokine is probably

关 键 词：反复种植失败 促炎因子 抑炎因子 子宫内膜容受性 

分 类 号：R[医药卫生]