烟雾病患者血清Ang-1、Ang-2及HIF-1α含量变化及意义  

Changes in serum contents of Ang-1, Ang-2 and HIF-1α in patients with Moyamoya disease and their meanings

作　　者：王强[1] 李俊[2] 陈刚[2] 盛柳青[2] 李欢欢[1] 刁波[2] 马廉亭[2] 

机构地区：[1]南方医科大学武汉临床学院神经外科,武汉430070 [2]广州军区武汉总医院神经外科,武汉430070

出　　处：《中国临床神经外科杂志》2013年第4期214-216,共3页Chinese Journal of Clinical Neurosurgery

基　　金：湖北省自然科学基金资助项目(2011CDC156);湖北省科技计划与开发项目(2010BCB012)

摘　　要：目的探讨血管生成素1、2(Ang-1、Ang-2)及低氧诱导因子1α(HIF-1α)在烟雾病发病中的作用。方法采用酶联免疫吸附法检测26例烟雾病患者及9例健康成人血清Ang-1、Ang-2及HIF-1α浓度,并进行统计学对比分析。结果烟雾病患者血清Ang-1浓度显著低于健康成人(P<0.05),Ang-2及HIF-1α浓度则与健康成人无明显差异(P>0.05);中、后期烟雾病患者血清HIF-1α浓度较早期患者显著增高(P<0.05);血清Ang-1、Ang-2浓度在不同性别、类型、分期烟雾病患者之间均无统计学差异(P>0.05)。结论维持血管稳定性重要因子Ang-1的减少在烟雾病的发病中可能起重要作用。Objective To investigate the roles of angiopoietin-1 （Ang-1）, angiopoietin-2 （Ang-2） and hypoxia-inducible factor-1α （HIF-1α） in the pathogenesis of Moyamoya disease. Method The serum contents of Ang-1, Ang-2 and HIF-1α were determined by enzyme-linked immunosorbent assay in 26 patients with Moyamoya disease and 9 healthy subjects. Results The serum content of Ang-1 was significantly lower in the patients with Moyamoya disease than that in 9 healthy subjects （P〈0.05）, there were no significant differences in the serum contents of Ang-2 and HIF-1α between the patients with Moyamoya disease and the healthy subjects. Conclusion It is suggested that the decrease in the serum content of Ang-1 may play an important role in the pathogenesis of Moyamoya disease.

关 键 词：烟雾病 血管生成素1 血管生成素2 低氧诱导因子1Α 

分 类 号：R743.4[医药卫生—神经病学与精神病学]