VEGF和CXCR4在弥漫大B细胞淋巴瘤中的表达及其临床意义  

Expressions of VEGF and CXCR4 in Diffuse Large B Cell Lymphoma and Their Clinical Significances

作　　者：郭青[1] 王加菊[1] 李芳[1] 杨洪亮[1] 于泳[1] 赵智刚[1] 王晓芳[1] 王亚非[1] 张翼鷟[1] 

机构地区：[1]天津医科大学附属肿瘤医院血液科,天津市肿瘤防治重点实验室,天津300060

出　　处：《中国实验血液学杂志》2013年第2期383-386,共4页Journal of Experimental Hematology

摘　　要：本研究旨在探索VEGF和CXCR4在弥漫大B细胞淋巴瘤(DLBCL)患者血清中的表达水平,两者之间的相关性及对预后的影响。用ELISA法检测44例初治DLBCL患者和20例健康人血清中VEGF和CXCR4的表达水平,并收集临床资料进行相关性分析和生存分析。结果表明,DLBCL患者血清中VEGF和CXCR4的表达水平明显高于正常对照组(P<0.05);VEGF和CXCR4的表达水平存在显著正相关(r=0.743,P<0.05);且VEGF的表达水平与LDH、免疫分型、结外受累数、Ann Arbor分期和ECOG评分相关(P<0.05);CXCR4在DLBCL患者血清中的表达水平与LDH、免疫分型、结外受累数和Ann Arbor分期相关(P<0.05);单因素分析显示,LDH、免疫分型、结外受累数、Ann Arbor分期、VEGF和CXCR4是患者总生存(OS)的预后影响因素(P<0.05);多因素分析显示,免疫分型和血清中CXCR4的表达水平是影响患者OS的独立不良预后因素(P<0.05)。结论:VEGF和CX-CR4在DLBCL患者血清中显著高表达,且二者的表达水平存在正相关,CXCR4是影响患者OS独立不良预后因素,联合阻断VEGF和CXCR4可能成为淋巴瘤的治疗新思路。This study was aimed to investigate the expression levels of CXCR4 and VEGF in serum of patients with DLBCL and their clinical significances. The peripheral blood of 44 patients with newly diagnosed DLBCL and 20 healthy adults as a control group were chosen for study. And the expression levels of CXCR4 and VEGF in serum were detected by ELISA. The results showed that the expressions of VEGF and CXCR4 in DLBCL patients were higher than those in the control group （P 〈 0.05 ）. The expression of VEGF was positively correlated with the expression of CXCR4 in DLBCL patients, and the correlation coefficient was 0.743 （ P 〈 0.05 ）. The VEGF expression in DLBCL patients was correlated with LDH, immunotyping, the number of extranodal involvements, Ann Arbor staging and ECOG performance score; while the expression of CXCR4 was correlated with LDH, immunotyping, the number of extranodal involvements and Ann Arbor staging. Univariate analysis showed that LDH, extranodal involvements, immunotyping, Ann Arbor staging, CXCR4 and VEGF were associated with OS. Multivariate analysis showed that the immunotyping and CXCR4 expression independently associated with OS. It is concluded that both expression levels of VEGF and CXCR4 are significant higher than those in the control group. CXCR4 expression positively correlates with VEGF expression and displays a prognostic significance for OS. This study suggestes that combined targeting VEGF and CXCR4 may become a novel therapeutic strategy for diffuse large B cell lymphoma.

关 键 词：弥漫大B细胞淋巴瘤 血管内皮生长因子 CXCR4 

分 类 号：R733.1[医药卫生—肿瘤]