液基细胞学联合人乳头瘤病毒-DNA检测在宫颈病变中的诊断价值  

The Value of Thinprep Cytologic Test in Conjunction With Human Papilloma Virus-DNA Testing in the Diagnosis of Cervical Disease

作　　者：胡静[1] 王冬芹[1] 

机构地区：[1]湖北省黄石市妇幼保健院,湖北黄石435000

出　　处：《中华妇幼临床医学杂志（电子版）》2013年第2期196-198,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的探讨液基细胞学(TCT)联合人乳头瘤病毒(HPV)-DNA检测对宫颈病变的诊断价值。方法选择2012年1月至8月于本院接受宫颈病变筛查的5289例妇女为研究对象,并按照检测方式分为TCT组(n=2803,TCT检测),HPV-DNA组(n=1046,HPV-DNA检测)和联合组(n=1440,TCT联合HPV-DNA检测)。比较3组患者宫颈病变阳性检出率及病理学阳性符合率(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书)。3组患者年龄等一般情况比较,差异无统计学意义(P>0.05)。结果 3组患者宫颈病变阳性检出率比较,差异均无统计学意义(P>0.05)。联合组患者检测结果病理学阳性符合率分别与TCT组和HPV-DNA组比较,差异均有统计学意义(P<0.05)。结论 TCT联合HPV-DNA检测法可提高宫颈病变诊断准确性,是筛查宫颈早期病变较为可靠的检测方法。Objective To evaluate the value of thinprep cytologic test（TCT） in conjunction with human papilloma virus（HPV）-DNA testing in the diagnosis of cervical disease. Methods From January to August 2012,5289 women who accepted cervical disease screening were included in the study, and were divided into TCT group（n = 2803）, HPV-DNA group （n= 1046） and combination group（n= 1440）. The positive rate and positive coincidence rate between test results and pathological results were compared among three groups. There was no significant difference in general condition among three groups （P〉0.05）. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Maternal and Child Health Care Hospital of Huangshi. Informed consent was obtained from each patient. Results There was no significant difference in positive rate among three groups（P〉0.05）. The positive coincidence rate between test results and pathological results in combination group were obviously higher than those of TCT group and HPV-DNA group（P〈0.05）. Conclusions The TCT combine with HPV-DNA test can improve the diagnostic accuracy of cervical disease, and prove to be a more reliable method to the early stage of cervical disease.

关 键 词：液基细胞学 人乳头瘤病毒 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]