子宫肌瘤与体质指数及腰臀比关系  

Body mass index, waist to hip ratio and uterine leiomyoma

作　　者：翟淑娜[1] 李岩[1] 姜腾轩[1] 孙文慧[1] 闫佳[1] 卢智泉[1] 

机构地区：[1]辽宁医学院流行病学教研室,辽宁锦州121001

出　　处：《中国现代医学杂志》2013年第6期42-46,共5页China Journal of Modern Medicine

基　　金：辽宁医学院"奥鸿大学生创新课题基金"(No:2011YD45)

摘　　要：目的探讨中老年女性BMI及WHR与发生子宫肌瘤（UL）危险性的关系。方法采取以医院为基础的研究。病例为术后经病理证实为UL,年龄在35~67岁的280例患者,对照为未患UL及其他可能的妇科疾病,同期入住同一病房的280例患者。采用自行设计的调查表对研究对象进行调查,内容包括一般情况、生活方式以及既往史等,同时对身高、体重、WC及臀围进行测量。采用多因素Logistic回归模型对患者BMI、WHR与UL关系的OR及其相应的95%CI进行估计。结果与BMI和WHR最低四分位数的对照组相比,病例组BMI为最高四分位数者发生UL的危险性显著增加,病例组WHR为最高四分位数者发生UL的危险性也增加,进一步调整了多种潜在性混杂因素后,BMI最高四分位数者发生UL的危险性也升高。同样地,将WHR引入Logistic回归模型中,分析的结果并未发生改变。结论 BMI和WHR的升高可使发生UL的危险性增加,超重和肥胖,尤其是向心性肥胖为UL的重要危险因素,因此倡导通过改变生活方式及饮食习惯,保持正常体重、BMI及WHR则可有效地预防子宫肌瘤的发生。【Objective】To explore the association between body mass index（BMI）,waist to hip ratio（WHR） and uterine leiomyoma（UL） risk in middle aged and elderly women.【Methods】A hospital-based case-control study was conducted.Cases（n =280） were surgically and histologically confirmed with UL with 35～67 years old,and controls（n =280） were women admitted to same hospital for different diseases not related with gynecologic diseases.Using a structured interviewer-administrated questionnaire that included information on sociodemographic characteristics,lifestyle habits,detailed medical history,simultaneously,all subjects were interviewed,and height,weight,waist and hip circumference of the subjects were measured.The odds ratios（OR） and 95% confidence intervals（CI） of UL for BMI and WHR were estimated with unconditional multiple logistic regression models.【Results】Compared to women in the lowest quartile of BMI and WHR,the risk of UL for women in the highest quartiles significantly increased.After adjustment for multiple potential confounders,BMI and WHR were also positively associated with UL,women in the highest quartiles of BMI had approximately two times the risk of UL as did those in the lowest quartile.Similarly,compared to women in the lowest quartiles of WHR,those in the highest quartiles increased.It was showed increased UL risk with increasing WHR.【Conclusion】BMI and WHR increase UL risk,overweight and obesity,especially central obesity,are important risk factors of UL.Thus,UL should be effectively prevented through changing unhealthy lifestyle and dietary habit,keeping normal weight,BMI and WHR.

关 键 词：子宫肌瘤 体质指数 腰臀比 病例对照研究 

分 类 号：R737.33[医药卫生—肿瘤]