血管性帕金森综合征和帕金森病患者智能与事件相关电位的对比研究  

A compared study on intelligence and event-related potential in patients with vascular parkinsonism and Parkinson's disease.

作　　者：张巍[1] 雷征霖[1] 孙秀兰[1] 宋春莉[1] 

机构地区：[1]大连医科大学第一临床学院神经内科,116011

出　　处：《脑与神经疾病杂志》2000年第4期201-204,共4页Journal of Brain and Nervous Diseases

摘　　要：目的:对血管性帕金森综合征(VP)患者和帕金森病(PD)患者的智能和事件相关电位(ERP)进行对比研究,以期探讨两者智能障碍及其电生理变化的特点。方法:用简易智能状态量表对51例VP及50例PD进行评分,并检测其ERP各波的潜伏期及波幅,并与32例正常者作对照。结果:1.VP组痴呆的发生串明显高于PD组;重症痴呆发生率高,提示症状重。2.VP组的N_2、P 300潜伏期较PD组、正常对照组均明显延长,P_(300)波幅较两者均明显降低。3.VP组痴呆者较非痴呆者N_2、P_(300)潜伏期明显延长,P_(300)波幅明显降低,4.VP组痴呆者较PD组痴呆者N_2、P_(300)潜伏期明显延长,P_(300)波幅明显降低。结论:VP与PD比较,智能障碍发生率高,程度重,电生理改变更明显。Objective We studied patients of vascular parkinsonism(VP) with those Parkinson's diseaes (PD) on intelligence and event-related potential (ERP) in order to find characteristics of intellectual impairment and electrophysiology. Methods 51 cases VP 50 cases PD and 32 cases of healthy controls were measured by using Mini Mental State Examination (MMSE) and latent period and amplitude of all the waves of ERP. Results There high incidence of dementia and severe manifestation in VP group. The latent perios of N2 and P300 significantly prologed and the amplitude of P300 markedly lowered occured in thefollowing comparisons: comparing VP with PD and control group; comparing demented with nondementedVP group; comparing demented VP and demented PD group. Conclusions VP have a high incidence of intelligence impairment severe manifestation and obvious electrophysiological alterations.

关 键 词：血管性帕金森综合征 智能 痴呆 事件相关电位 

分 类 号：R742.5[医药卫生—神经病学与精神病学]