卵巢良恶性疾病上皮钙粘合素和α-连环素的表达及意义  

The Expression of E-cadherin(E-Cad)、α-catenin(α-C) and Their Significance in Benign and Malignant Lesions of Ovary

作　　者：李玲[1] 

机构地区：[1]湖南医科大学附属第二医院妇产科,湖南长沙410011

出　　处：《中国医师杂志》2000年第7期396-398,共3页Journal of Chinese Physician

摘　　要：本文通过ABC免疫组化法研究E -Cad、α -C在卵巢良恶性疾病组织中的表达及其生物学意义。结果表明卵巢浆液性腺瘤和绝大部分粘液性腺瘤 ( 12 / 14)的E -Cad、α -C表达明显地高于卵巢恶性肿瘤 ,与卵巢恶性肿瘤病理类型有一定关系 ,以浆液性囊腺癌阳性表达率最高 ,而无性细胞瘤和颗粒细胞瘤均是阴性表达或表达下降 ;临床分期Ⅰ期、术后生存期 >1年及未转移病例E -Cad、α -C阳性表达率均明显高于临床分期Ⅲ～Ⅳ期、术后生存期≤ 1年及发生转移的病例 ,差异均显著或高度显著。说明E -Cad、α -C表达可能与卵巢癌发生发展。The expressive characterstics of E-Cad,α-C and their biological significances in ovary with benign and malignant lesions were studied by using immunohistochemical method of avidin-biotin complex.The results were as follows.The positive rates of E-Cad,α-C were significantly higher in serous cystadenoma(9/9,9/9) and mucinous cystadenoma(12/14,12/14) than that in ovary with malignant lesions(14/38,15/38).The correlations were found among the expressions of E-Cad and α-C and the pathological types of malignant lesions of ovary,the positive rates of E-cad,α-C were highest in serous cystadenocarcinomas,but the positive cases weren't found in granulosa cell tumor and dysgerminoma.The positive rates of E-Cad,α-C were significantly higher in the cases of clinical stage I,survival ≥1 year,and without metastasis than thoes of clinical stage Ⅲ～Ⅳ,survival<1 year,and with metastasis.It suggests that the expressions of E-Cad,α-C might be related to the carcinogenesis and development,biological behaviors and prognosis of malignant lesions in ovary.

关 键 词：卵巢肿瘤 上皮内粘附分子类 免疫组织化学 

分 类 号：R730.4[医药卫生—肿瘤]