急性脑血管病并渗透性肾病尿Tamm-Horsfall蛋白的变化  

Changes of Urine Tamm-Horsfall Protein in Acute Cerebrovascular Disease Combined with Osmotic Nephropathy

作　　者：刘绪青[1] 

机构地区：[1]湖北省宜昌市中心人民医院内科,湖北宜昌443000

出　　处：《中国医师杂志》2000年第7期401-402,共2页Journal of Chinese Physician

摘　　要：检测了 54例急性脑血管病并渗透性肾病 (ON)患者尿Tamm -Horsfallprotein粘蛋白 (THP)、尿β2 -微球蛋白 ( β2 -MG)、血清尿素氮 (BUN)及肌酐 (Cr) ,同时设对照组。结果老年组 (年龄≥ 60岁 )及中青年组尿THP分别为 ( 8 9± 5 6和 15 2± 8 7)mg/ 2 4h均显著低于对照组 (P <0 0 1) ,且老年组尿THP显著低于中青年组 (P <0 0 1) ,54例患者尿THP下降率为 10 0 %。而两组的尿β2 -MG、血BUN、Cr均显著高于对照组 (P<0 0 1) ,且老年组显著高于中青年组 (P <0 0 1)。尿THP与 β2 -MG呈负相关 (r =- 0 681,P <0 0 1)。表明急性脑血管病并ON存在着明显的肾小管间质损伤 ,老年患者更明显。尿THP是一个诊断ON的敏感指标。对急性脑血管病患者 ,临床上应注意正确使用高渗脱水剂 。The contents of urine Tamm-Horsfall protein (THP),β 2-microglobin (β 2-MG),blood urine nitrogen (BUN) and creatinine(Cr) in fifty-four patients with acute cerebrovascular disease(ACVD) were measured.The results were as follows:⑴The amount of urine THP excretion in the elder(≥60 years) group and the young-middle age group were distinctly lower than those of the control group[P<0 01,(8 9±5 6)mg/24h,(15 2±8 7)mg/24h vs (41 8±13 5)mg/24h,respectively],and the urine THP content in the elder group was markedly lower the young-middle age group(P<0 01)。⑵The urinary THP concentrations in 54 patients with ACVD were all decreased(100%),but the contents of urine β 2-MG,BUN and Cr in the two expermental groups were obviously higher than that of control group(P<0 01),and the three markers levels in elder group were significantly higher than that in young-middle age group.⑶There was negative correlation between urine THP and β 2-MG (r=-0 681,P<0 01)。Based on the findings,we believe that the patients with ACVD exist obviously renal tubular interstitial injury,especially in the senile patients.

关 键 词：脑血管病 肾病渗透性 塔霍蛋白 药物治疗 

分 类 号：R743[医药卫生—神经病学与精神病学] R692.5[医药卫生—临床医学]