肝星状细胞与转移性肝肿瘤  

Hepatic stellate cells and metastatic liver neoplasms

作　　者：徐向南[1] 肖永胜[1] 樊嘉[1] 

机构地区：[1]复旦大学附属中山医院肝癌研究所,上海市200032

出　　处：《世界华人消化杂志》2013年第10期873-879,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81141087~~

摘　　要：作为一种多能的间质细胞,肝星状细胞(hepatic stellate cells,HSC)最早是由Kupffer在19世纪首次描述,因其可以分化为高增殖性并具有胶原分泌能力的肌成纤维细胞,从而参与促结缔组织增生与转移性肿瘤生长而被视为肝脏微环境的一部分.本文旨在就肿瘤细胞与HSC在肝脏微环境中的相互关系作一综述,并讨论肿瘤来源因子激活HSC促进肿瘤生长转移的机制.可以将肝肿瘤细胞与HSC在肝脏微环境中的相互关系形象地视为一个"放大回路".HSC的激活是一个由转化生长因子-β(transforming growth factor-β)与血小板源性生长因子(platelet-derived growth factor)信号通路等多种因素调节的复杂过程.HSC为预防肿瘤转移提供了可能的治疗靶点,进而有效地控制肿瘤的转移并提高患者的生存率.Hepatic stellate cells （HSCs） were first described in the 19th century as a type of multi-functional mesenchymal cells. They are considered as the component of liver microenvironment because of their capacity to differentiate into myofibroblasts which are highly proliferative and have collagen secretion capacity. This paper reviews the interactions between tumor cells and HSCs in liver microenvironment and discusses mechanisms by which tumor-derived factors activate HSCs, and in turn, activated HSC promotes metastatic tumor growth. The interactions between tumor cells and HSCs in liver microenvironment can be regarded as an ＂amplification loop＂. The activation of HSCs is a complex process that is regulated by mul-tiple pathways, such as the transforming growth factor-β and platelet-derived growth factor signal- ing pathways. HSCs provide a possible therapeutic target for liver metastases to effectively increase the survival of patients.

关 键 词：肝星状细胞 肝转移 微环境 肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]