肺良性转移性平滑肌瘤1例并文献复习  

Pulmonary benign metastasizing leiomyoma:a case report and review of the literature

作　　者：李静[1] 彭芳[1] 赵力[1] 

机构地区：[1]浙江医院病理科,浙江杭州310013

出　　处：《健康研究》2013年第2期120-122,F0003,共4页Health Research

摘　　要：目的分析肺良性转移性平滑肌瘤(pulmonary benign metastasizing leiomyoma,PBML)的临床和病理特点,讨论其发生机制及治疗方法。方法收集1例PBML患者的临床资料,对其肺活检组织进行光镜观察及免疫组化标记,并查阅资料复习文献。结果 37岁女性,子宫平滑肌瘤术后9年。胸腔镜活检病理镜下见平滑肌组织瘤样增生,内见少量上皮衬覆的管腔样结构,未见坏死和核分裂象,与原发子宫平滑肌瘤形态相似。结合临床情况及免疫标记,诊断为肺良性转移性平滑肌瘤。结论 PBML是一种罕见疾病,多有子宫平滑肌瘤病史,主要转移至肺,手术与激素治疗为主,预后多数良好。Objective The study attempted to analyze the clinical and pathologic characteristics of PBML and research the pathogenesis and treatment for the disease. Method The clinical, histopathologic and immunohistologic characteristics of PBML of one patient per se were studied in light of a review of relevant literatures. Results The patient, a 37-year old, child-bearing female, who underwent hysterectomy of her uterus leiomyoma 9 years ago, was found to have PBML. Pathologic diagnosis after surgery showed that nodules consist of proliferating smooth muscle cells, some lumenoid structure lined with epithelium in the tumor tissue, without the necrosis and karyokinesis. The pattern of tumor had similarity to the original tumor. The clinical data and immunohistochemistry together pointed to a case of BML. Conclusion PBML is a rare disease usually with a history of uterus leiomyoma. It mostly procreates metastasis to the lung. A combination of surgical resection and endocrine therapy as a means of treatment was found to procreate favorable prognosis for the case under study.

关 键 词：良性转移性平滑肌瘤 子宫肌瘤 发生机制 

分 类 号：R365[医药卫生—病理学]