舍曲林合并利培酮对慢性精神分裂症认知缺损的疗效研究  

Effects of sertraline and risperidone combination on cognitive impairment in chronic schizophrenic patients

作　　者：潘金灯[1] 叶小芳[1] 

机构地区：[1]杭州市公安局安康医院,浙江杭州311113

出　　处：《健康研究》2013年第2期128-130,133,共4页Health Research

摘　　要：目的研究舍曲林对慢性精神分裂症认知损害的疗效。方法将56例慢性精神分裂症认知损害患者配对分为舍曲林+利培酮组(研究组)与利培酮组(对照组)。分别对两组患者进行划消测验、临床记忆量表和威斯康星卡片分类测验(WCST)的测查。结果治疗前,两组患者在划消测验完成时间、漏划数字和错划数字以及WCST卡片分类测验均无显著性差异(P均>0.05)。治疗后,研究组漏划数以及错划数较治疗前显著减少,WCST各项指标较治疗前也有显著改善(P均<0.01),而对照组治疗前后差异无显著性(P>0.05)。结论舍曲林对慢性精神分裂症患者的认知损害有一定的改善作用。Objective The study was intended to understand the effects of Sertraline and risperidone combination on cognitive impairment in chronic schizophrenia patients. Method sixty cases of chronic schizophrenia patients with cognitive impairment were into two groups, with one group administered with Sertraline and risperidone combination and the other treated with risperidone only. Both groups were subjected to cancellation test, clinical memory scale and Wisconsin card sorting test （WCST） test. Results Before treatment, no significant differences were found between the two groups of patients in the time for completing the cancellation test, ＇ leakage zoned digital and wrongly classified figures＇ and the WCST card sorting test（P 〉 O. 05）. At the end of the study, ＇ leakage designated number and the wrong program number＇ were found to have reduce significantly in the experiment group. The various WCST indicators in the experiment group have also been significantly improved （ P 〈 0. 01 ） , while the control group did not show much difference before and after treatment（P 〉0.05）. Conclusion Sertraline and risperidone combination can noticeably rectify cognitive impairment in patients suffering chronic schizophrenia.

关 键 词：慢性精神分裂症 认知功能 舍曲林 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]