维持性血液透析患者血浆游离氨基酸检测的临床意义  

The clinical significance of determination of plasma concentrations of free amino acids in maintenance hemodialysis patients

作　　者：葛煜强[1] 徐元钊[1] 袁敏[1] 丁小强[1] 廖履坦[1] 

机构地区：[1]上海医科大学附属中山医院肾内科,200032

出　　处：《中国实用内科杂志》2000年第4期211-213,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的　对维持血液透析患者的血浆游离氨基酸进行测定和分析。方法　用氨基酸自动分析仪测定 15例血透患者在一次透析前后的血浆氨基酸谱。结果　血透患者在透析前的必需氨基酸除苯丙氨酸外均较正常对照组降低 ,其中以缬氨酸、亮氨酸和组氨酸下降为显著 ;非必需氨基酸中精氨酸、甘氨酸和鸟氨酸明显升高 ;酪氨酸/苯丙氨酸和丝氨酸 /甘氨酸的比值较对照组明显降低。患者在一次透析后的必需和非必需氨基酸均低于透析前水平。结论　血透患者氨基酸异常的原因可能与蛋白质摄入不足。Objective\ To determine and analyze the plasma free amino acids in maint hemodialysis patients.Methods\ The plasma concentrations of amino acids were detected by auto amino acid analyzer in 15 hemodialysis patients before and after one procedure of hemodialysis.Results\ The levels of some essential amino acids like valine,leucine and histidine were significantly lower than those of normal controls.The levels of some nonessential amino acids,especially arginine,glycine and ornithine were significantly elevated than those of normal controls.The ratios of tyrosine/phenylalanine and serine/glycine were also significantly lower than normal controls.The concentrations of all the amino acids decreased after one dialysis procedure.Conclusion\ The abnormal amino acids pattern of hemodialysis patients may be related with low protein intake,toxic effects of uremia and metabolic acidosis.

关 键 词：维持性血液透析 游离氨基酸 血浆 

分 类 号：R459.5[医药卫生—治疗学] R446.112[医药卫生—临床医学]