地塞米松治疗蛛网膜下腔出血性头痛的疗效探究  

Study on the efficacy of dexamethasone in treatment of headache after subarachnoid hemorrhage

作　　者：卢荣璋[1] 刘燕娜[1] 

机构地区：[1]汕头市中心医院,515031

出　　处：《国际医药卫生导报》2013年第8期1145-1148,共4页International Medicine and Health Guidance News

摘　　要：目的 探讨地塞米松治疗蛛网膜下腔出血性头痛的疗效。方法收集蛛网膜下腔出血性头痛患者42例，予20％甘露醇250ml静推的同时，静脉注射地塞米松1mg（A组），10mg（B组），和鞘内注射地塞米松1mg（C组），10mg（D组），以及未注射地塞米松的对照组（对照组）。结果对照组于治疗后头痛评分仍高达5．8分，静脉注射组（A组和B组）的评分未见明显降低。鞘内注射1mg和10mg地塞米松（C组和D组）均可明显降低头痛程度（P〈0．05）。D组的持续时间明显高于对照组及其他治疗组的，差异有统计学意义（P〈0．01）。结论鞘内注射地塞米松10mg可明显提高蛛网膜下腔出血性头痛的疗效。Objective To investigate the efficacy of dexamethasone in treatment of headache after subarachnoid hemorrhage （SAH）. Methods 42 patients with headache after SAH were randomly divided into 5 groups, patients in group A and B were injected intravenously with 1 mg and 10 mg of dexamethasone, patients in group C and D were injected intrathecally with 1 mg and 10 mg of dexamethasone, and patients without dexamethasone injection were considered as control group. AU patients received mannitol simultaneously. Results The evaluation score of headache of group D decreased （P〈0.01）, and prolonged the lasting time of remission （P〈0.01）, and increased the efficacy （ X2=17.631, P〈0.01）. Conclusion Intrathecal injection of 10 mg of dexamethasone could exert optimal curative effect on headache after SAH.

关 键 词：地塞米松 蛛网膜下腔出血 头痛 

分 类 号：R743.35[医药卫生—神经病学与精神病学]