鼻咽癌调强放疗与三维适形放疗口腔反应临床分析  

Clinical analysis of oral reaction of intensity modulated radiotherapy and three-dimensional conformal radiotherapy for nasopharyngeal carcinoma

作　　者：张相国[1] 陈志仁[1] 徐晓南[1] 廖卫坚[1] 赖淑贞[1] 刘洪波[1] 

机构地区：[1]汕头大学附属粤北人民医院放疗科,广东韶关512026

出　　处：《实用临床医药杂志》2013年第7期149-151,共3页Journal of Clinical Medicine in Practice

摘　　要：目的观察鼻咽癌调强放疗与三维适形放疗的口腔黏膜及口干反应。方法将本院收治的82例鼻咽癌患者随机分为2组,每组41例,其中观察组行调强放疗,对照组行三维适形放疗,比较2组患者治疗后的口干及口腔黏膜反应。结果观察组口腔黏膜反应多为Ⅰ、Ⅱ级,少数为Ⅲ级反应,口干反应多为Ⅰ、Ⅱ级,未出现Ⅳ级反应;对照组的口腔黏膜反应多为Ⅱ、Ⅲ级,口干反应也同样多为Ⅱ、Ⅲ级。观察组的黏膜反应、口干明显轻于对照组(P<0.05)。结论调强放疗与三维适形放疗治疗鼻咽癌均可获得满意疗效,但调强放疗较三维适形放疗口腔毒副反应轻,更为安全,且缩短住院时间,值得临床推广应用。Objective To observe nasopharyngeal carcinoma reaction of intensity modulated radiation therapy and three - dimensional conformal radiotherapy for oral mucosa reaction and xeros- tomia. Methods Eighty - two nasopharyngeal carcinoma patients in our hospital were randomly di- vided into two groups, 41 in each group. The observation group received intensity modulated radia- tion therapy, while the control group underwent three - dimensional conformal radiotherapy. Xeros- tomia and oral mucosa reactions of the two groups after treatment were compared. Results Most of the oral mucosa reactions of the observation group were grades I and Ⅱ. Only few of them were grade Ⅲ. Most of xerostomia reactions were grades Ⅱ and . Grade Ⅱ reactions were not observed. Most of the oral mucosa reactions of the control group were grades Ⅱ and Ⅲ ~ Most of the xerosto- mia reactions were grades Ⅱ and m. The oral mucosa reactions and xerostomia were lighter in the observation group than in the control group （P 〈 0.05）. Conclusion Both intensity modulated ra- diotherapy and three- dimensional conformal radiotherapy for nasopharyngeal carcinoma bring satis- factory curative effects. But the intensity modulated radiotherapy may have lighter oral toxicity, more safety, and shorter hospital stay. Thus it is worthy of clinical application.

关 键 词：鼻咽肿瘤 调强放疗 三维适形放疗 口腔反应 

分 类 号：R739.6[医药卫生—肿瘤]